Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
Stable Identifier
R-MMU-112339
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P31938
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
p-2T-MAP2K1 [cytosol] (Mus musculus)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
Inactivation of MAP2K1 by CDK1 (Mus musculus)
p-2T-MAP2K1 [cytosol] (Mus musculus)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
p-2T-MAP2K1 [cytosol] (Mus musculus)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P31938 Map2k1
Gene Names
Map2k1, Mek1, Prkmk1
Chain
chain:1-393
Reference Genes
BioGPS Gene:26395 Map2k1
KEGG:mmu:26395 Map2k1
Monarch:26395 Map2k1
NCBI Gene:26395 Map2k1
UCSC:P31938 Map2k1
Reference Transcript
RefSeq:NM_008927.3 Map2k1
Other Identifiers
10594447
1416351_at
17528160
26395
4313217
4357592
4421601
4466788
4511579
4542044
4699752
4834700
4931127
5131293
5332431
5372086
5456287
5457116
5527956
5533806
5541097
5558203
92585_at
A_51_P241074
A_65_P17605
GE40374
GE42551
GO:0000165
GO:0003013
GO:0003056
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005813
GO:0005815
GO:0005816
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005925
GO:0005938
GO:0006355
GO:0006468
GO:0006979
GO:0007018
GO:0007507
GO:0008285
GO:0008286
GO:0010508
GO:0010628
GO:0010629
GO:0014044
GO:0014069
GO:0016020
GO:0016740
GO:0019901
GO:0021697
GO:0030154
GO:0030182
GO:0030216
GO:0030295
GO:0030335
GO:0030424
GO:0030425
GO:0030878
GO:0031267
GO:0031410
GO:0031435
GO:0032402
GO:0032839
GO:0032872
GO:0032968
GO:0034111
GO:0035987
GO:0038133
GO:0042552
GO:0043204
GO:0043226
GO:0043410
GO:0043539
GO:0044342
GO:0044877
GO:0045893
GO:0045933
GO:0046579
GO:0047496
GO:0048009
GO:0048313
GO:0048471
GO:0048538
GO:0048678
GO:0048679
GO:0048812
GO:0048856
GO:0048870
GO:0050772
GO:0051384
GO:0060020
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070328
GO:0070371
GO:0070372
GO:0070374
GO:0090170
GO:0090398
GO:0097110
GO:0098696
GO:0098772
GO:0098978
GO:0106310
GO:0140096
GO:1903226
GO:1903298
GO:2000641
GO:2001171
ILMN_2714534
L02526_s_at
mMC014391
Participates
as a member of
p-2T-MAP2K1 [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
phospho-p-T286,T292-MAP2K1 [cytosol]
Mek1 [cytosol]
Phospho Mek1 [cytosol]
Inferred From
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 286 (in Homo sapiens)
Coordinate
286
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 292 (in Homo sapiens)
Coordinate
292
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_032953.1
ENSEMBL
ENSMUST00000005066
,
ENSMUSP00000005066
ZINC - Substances
MP2K1_MOUSE
ZINC target
P31938
PRO
P31938
GlyGen
P31938
MGI
1346866
ZINC - Predictions - Purchasable
MP2K1_MOUSE
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.558
4
UniProt:Q9ESN9-2 MAPK8IP3
0.499
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text