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phospho-p-S317,S345-CHEK1 [nucleoplasm]
Stable Identifier
R-MMU-113838
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
O35280
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G1/S DNA Damage Checkpoints (Mus musculus)
p53-Independent G1/S DNA damage checkpoint (Mus musculus)
p53-Independent DNA Damage Response (Mus musculus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
G2/M Checkpoints (Mus musculus)
Activation of ATR in response to replication stress (Mus musculus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Recruitment and activation of Chk1 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
CHEK1 phosphorylates TP53 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Recruitment and activation of Chk1 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
HDR through Homologous Recombination (HRR) (Mus musculus)
Homologous DNA Pairing and Strand Exchange (Mus musculus)
Presynaptic phase of homologous DNA pairing and strand exchange (Mus musculus)
CHEK1 phosphorylates RAD51 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
Activation of CHEK1 at resected DNA DSBs (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by E2F6 (Mus musculus)
CHEK1 phosphorylates E2F6 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Phosphorylation (Mus musculus)
CHEK1 phosphorylates TP53 (Mus musculus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O35280
Reference Genes
BioGPS Gene:12649
ENSEMBL:ENSMUSG00000032113
KEGG:mmu:12649
Monarch:12649
NCBI Gene:12649
UCSC:O35280
Reference Transcript
RefSeq:NM_007691.5
Other Identifiers
103064_at
10592201
12649
1439208_at
1449708_s_at
1450677_at
17525503
4371287
4433960
4438921
4473964
4556351
4559221
4843644
4860701
4869126
4887838
4997544
5063104
5085175
5106956
5141293
5178247
5200545
5226930
5318248
5332418
5407263
5459614
5537733
5560992
AF016583_at
AF016583_g_at
A_51_P326499
A_55_P2000187
A_55_P2616463
GE34849
GO:0000077
GO:0000086
GO:0000228
GO:0000781
GO:0000785
GO:0000794
GO:0001833
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0006974
GO:0006997
GO:0007095
GO:0010468
GO:0010569
GO:0010972
GO:0012501
GO:0016740
GO:0018107
GO:0019904
GO:0032991
GO:0035402
GO:0042127
GO:0042770
GO:0043226
GO:0043231
GO:0044818
GO:0045787
GO:0045814
GO:0045839
GO:0046602
GO:0071260
GO:0071313
GO:0106310
GO:0140096
GO:1902742
GO:2000279
ILMN_2630974
ILMN_2666965
ILMN_3009652
mMC008043
Participates
as an output of
Recruitment and activation of Chk1 (Mus musculus)
Activation of CHEK1 at resected DNA DSBs (Mus musculus)
Other forms of this molecule
CHEK1 [cytosol]
CHEK1 [nucleoplasm]
Inferred From
p-S317,S345-CHEK1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 317 (in Homo sapiens)
Coordinate
317
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_031717.2
ENSEMBL
ENSMUSP00000034625
,
ENSMUST00000034625
,
ENSMUST00000172702
,
ENSMUSP00000134388
PRO
O35280
MGI
1202065
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