Reactome | Gp6 [plasma membrane]

Gp6 [plasma membrane]

Stable Identifier

R-MMU-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

GP6, P0C191

Locations in the PathwayBrowser

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Hemostasis (Mus musculus)

- Cell surface interactions at the vascular wall (Mus musculus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
- Platelet Adhesion to exposed collagen (Mus musculus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
  - GPVI binds Fyn and Lyn (Mus musculus)
    - GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
      - Gp6 [plasma membrane] (Mus musculus)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
      - GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
  - Interaction of GPVI and FceRI gamma (Mus musculus)
    - GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
      - Gp6 [plasma membrane] (Mus musculus)
    - Gp6 [plasma membrane] (Mus musculus)
- Platelet activation, signaling and aggregation (Mus musculus)
  - GPVI-mediated activation cascade (Mus musculus)
    - Binding of Syk tyrosine kinase (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - GPVI stimulates PI3K beta, gamma (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - SYK autophosphorylates (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
    - p-Y348-SYK dissociates (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Mus musculus)
        
        Gp6 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P0C191

Gene Names

Gp6

Reference Genes

BioGPS Gene:243816 Gp6

ENSEMBL:ENSMUSG00000078810

ENSEMBL:ENSMUSG00000078810.5 Gp6

KEGG Gene (Mus musculus):243816 Gp6

Monarch:243816 Gp6

NCBI Gene:243816 Gp6

UCSC:P0C191 Gp6

Reference Transcript

RefSeq:NM_001163014.1 Gp6

Other Identifiers

1446554_at

17485713

243816

4511447

4608119

4612512

4710785

4712175

4742850

4866115

4899705

4915141

4997068

5033603

5084339

5095622

5478406

5479140

5552304

5570633

A_51_P343189

A_55_P2016049

A_55_P2744126

GO:0005518

GO:0005886

GO:0007155

GO:0007596

GO:0007599

GO:0009986

GO:0016020

GO:0023052

GO:0038063

GO:0038064

GO:0038065

GO:0042060

GO:0045121

GO:0060089

GO:0070527

GO:0097197

GO:1990782

ILMN_2640560

ILMN_2640561

mMC014544

Participates

as an input of

Interaction of GPVI and FceRI gamma (Mus musculus)

as a component of

Inferred From

GP6 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001156486.1

Ensembl

ENSMUSG00000078810, ENSMUSP00000145740, ENSMUST00000206928

PRO

P0C191

MGI

1889810

HMDB Protein

HMDBP13515

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