Shp1 binds Jak2 in the receptor complex

Stable Identifier
R-MMU-1169250
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shp1 binds Jak2 in the receptor complex
SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).
Literature References
PubMed ID Title Journal Year
9111009 Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins

Hackett, RH, Wang, YD, Sweitzer, S, Feldman, G, Wood, WI, Larner, AC

J Biol Chem 1997
Participants
Input
Output
Orthologous Events
SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-14)
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