Prdm9 Trimethylates Histone H3 at Lysine-4

Stable Identifier
R-MMU-1214198
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
General
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PNG
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 | PPTX  | SBGN
Prdm9 Trimethylates Histone H3 at Lysine-4

Prdm9 (Meisetz) methylates histone H3 dimethylated at lysine-4 to yield histone H3 trimethylated at lysine-4 (Hayashi et al. 2005). The reaction occurs independently of and prior to the formation of double-strand breaks.

Literature References
PubMed ID Title Journal Year
16292313 A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Hayashi, K, Yoshida, K, Matsui, Y

Nature 2005
Participants
Input
Output
Catalyst Activity

histone methyltransferase activity (H3-K4 specific) of PRDM9:DNA Complex [nucleoplasm]

Physical Entity
PRDM9:DNA Complex [nucleoplasm] (Mus musculus)
Activity
histone methyltransferase activity (H3-K4 specific) (GO:0042800)
Orthologous Events
PRDM9 trimethylates histone H3 (Homo sapiens)
Authored
May, B  (2011-02-07)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Holloway, JK  (2011-02-05)
Lyndaker, A  (2011-02-25)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Created
May, B  (2011-02-11)
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