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About
What is Reactome ?
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HSP90 [cytosol]
Stable Identifier
R-MMU-1221657
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Mus musculus)
GTSE1 binds CDKN1A (Mus musculus)
GTSE1:CDKN1A:FKBPL:HSP90 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
HSF1 activation (Mus musculus)
Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)
HSF1:HSP90:PTGES3 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
AR binds AR agonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
AR binds AR antagonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
ATP binding to HSP90 triggers conformation change (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C1 binds NR3C1 agonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C2 binds NR3C2 antagonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C2:NR3C2 antagonists [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C2 binds fludrocortisone (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C2:fludrocortisone [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
PGR binds PGR agonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
PGR:PGR agonists [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
PGR binds PGR antagonists (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
PGR:PGR antagonists [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)
HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90 dimer:ATP:nascent protein [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
HSP90 binds TBK1 and IRF3 (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90:TBK1:IRF3 [cytosol] (Mus musculus)
HSP90:HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
MLKL binds HSP90:CDC37 (Mus musculus)
HSP90 [cytosol] (Mus musculus)
MLKL:HSP90:CDC37 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
RIPK3 binds HSP90:CDC37 (Mus musculus)
HSP90 [cytosol] (Mus musculus)
RIPK3:HSP90:CDC37 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
CUL5 mediates ubiquitination of ERBB2 (Mus musculus)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Drug-mediated inhibition of ERBB2 signaling (Mus musculus)
ERBB2 binds TKIs (Mus musculus)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
HSP90 [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
HSP90AA1 [cytosol]
(Mus musculus)
Participates
as a component of
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Mus musculus)
RIPK3:HSP90:CDC37 [cytosol] (Mus musculus)
MLKL:HSP90:CDC37 [cytosol] (Mus musculus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
as an input of
RIPK3 binds HSP90:CDC37 (Mus musculus)
MLKL binds HSP90:CDC37 (Mus musculus)
as a member of
HSP90:HSP90 [cytosol] (Mus musculus)
as an output of
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)
Inferred From
HSP90 [cytosol]
(Homo sapiens)
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