Reactome | FGG [extracellular region]

FGG [extracellular region]

Stable Identifier

R-MMU-140585

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

Q8VCM7

Locations in the PathwayBrowser

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Hemostasis (Mus musculus)

- Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
  - Common Pathway of Fibrin Clot Formation (Mus musculus)
    - factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
      - fibrin multimer [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)
      - fibrin multimer [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
      - Fibrinogen [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - n fibrin monomers -> fibrin multimer (Mus musculus)
      - fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - fibrin multimer [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
- Platelet activation, signaling and aggregation (Mus musculus)
  - Platelet Aggregation (Plug Formation) (Mus musculus)
    - Integrin alphaIIb beta3 signaling (Mus musculus)
      - Autophosphorylation of PTK2 at Y397 (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Autophosphorylation of SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
        
        Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Recruitment of GRB2 to p-PTK2 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Phosphorylation of pPTK2 by SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Release of CSK from SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - SYK activation by SRC (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - SYK binds to integrin alphaIIb beta3 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Translocation of PTK2 to Focal complexes (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
        
        Crk binding to p130cas (Mus musculus)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Recruitment of BCAR1 to PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
  - Response to elevated platelet cytosolic Ca2+ (Mus musculus)
    - Platelet degranulation (Mus musculus)
      - Exocytosis of platelet alpha granule contents (Mus musculus)
        
        Platelet alpha granule contents [extracellular region] (Mus musculus)
        
        Fibrinogen [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - FLT3 Signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Regulation of TLR by endogenous ligand (Mus musculus)
      - Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)
        
        FGA, FGB, FGG [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        TLR4:LY96:cleaved fibrinogen [plasma membrane] (Mus musculus)
        
        FGA, FGB, FGG [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)

Signal Transduction (Mus musculus)

- Integrin signaling (Mus musculus)
  - Integrin alphaIIb beta3 signaling (Mus musculus)
    - Autophosphorylation of PTK2 at Y397 (Mus musculus)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Autophosphorylation of SRC (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
      - Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
      - Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Recruitment of GRB2 to p-PTK2 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
      - Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Phosphorylation of pPTK2 by SRC (Mus musculus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Release of CSK from SRC (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - SYK activation by SRC (Mus musculus)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - SYK binds to integrin alphaIIb beta3 (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - Translocation of PTK2 to Focal complexes (Mus musculus)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
    - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
      - Crk binding to p130cas (Mus musculus)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
      - Recruitment of BCAR1 to PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
        
        fibrin monomer [extracellular region] (Mus musculus)
        
        FGG [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VCM7

Reference Genes

BioGPS Gene:99571

dbSNP Gene:99571

ENSEMBL:ENSMUSG00000033860

KEGG Gene (Mus musculus):99571

Monarch:99571

NCBI Gene:99571

UCSC:Q8VCM7

Reference Transcript

RefSeq:NM_133862.2

Other Identifiers

10492735

1416025_at

17398485

187811

4362931

4383874

4406552

4618562

4778001

4843127

4891009

4998749

5143917

5556346

5601112

93096_at

99571

A_51_P362176

aa244836_s_at

AAH19506

AAH19828

AAL02226

AF413206

AK149448

BAE28884

BC019506

BC019828

CCDS38462

ENSMUSG00000033860

ENSMUSP00000037018

ENSMUST00000048486

EntrezGene:99571

EntrezGene:Fgg

Fgg

Fgg-201

GE39792

GO:0002250

GO:0002376

GO:0003013

GO:0003674

GO:0005102

GO:0005198

GO:0005201

GO:0005575

GO:0005576

GO:0005577

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005886

GO:0005938

GO:0006464

GO:0006810

GO:0006950

GO:0007155

GO:0007160

GO:0007165

GO:0007267

GO:0007596

GO:0007599

GO:0008150

GO:0008219

GO:0009306

GO:0009897

GO:0009986

GO:0016192

GO:0022607

GO:0030168

GO:0031012

GO:0031091

GO:0031410

GO:0031639

GO:0032991

GO:0034116

GO:0034622

GO:0042730

GO:0042803

GO:0043167

GO:0043226

GO:0045087

GO:0045202

GO:0045907

GO:0045921

GO:0046872

GO:0050714

GO:0050839

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070374

GO:0070527

GO:0072378

GO:0072562

GO:0090277

GO:0090331

GO:1902042

GO:2000352

ILMN_1223400

ILMN_2832105

IPR002181

IPR012290

IPR014715

IPR014716

IPR020837

IPR036056

IPR037581

MGI:95526

mMC017786

NM_133862

NP_598623

PF00147

PF08702

Q3UEM7

Q3UER8

SM00186

SM01212

uc008ppe.2

UPI000002895B

Participant Of

hasComponent

hasMember

FGA, FGB, FGG [extracellular region]

Other forms of this molecule

FGG [platelet alpha granule lumen]

phospho-p-FGG [endoplasmic reticulum lumen]

FGG [endoplasmic reticulum lumen]

FGG [plasma membrane]

Inferred From

FGG [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_598623.1

PRO

Q8VCM7