Interaction of Src kinases with c-Kit

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
Interaction of Src kinases with c-Kit

Binding of SCF to KIT induces the activation and rapid increase in kinase activity of multiple Src family kinases (SFK), including Src, Lck, Tec, Fyn, and Lyn (Timokhina et al. 1998, Krystal et al. 1998, Linnekin et al. 1997, Lennartsson et al. 1999, Tang et al. 1994, Samayawardhena et al. 2007). The tyrosine residues Y568 and Y570 in KIT juxtamembrane region are involved in the association of SFKs (Price et al. 1997).
SFKs recruited to KIT induce proliferation and chemotaxis in primary hematopoietic progenitor cells or bone marrow derived mast cells (O'Laughlin-Bunner et al. 2001). SCF activated SFKs also mediate a critical signal for lymphocyte development (Agosti et al. 2004). Timokhina et al. demonstrated that Src kinase and PI3-kinase signaling pathways converge to activate Rac1 and JNK after SCF stimulation in BMMC, promoting cell proliferation (Timokhina et al., 1998, Reber et al. 2006 ).

Literature References
PubMed ID Title Journal Year
9799234 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

Timokhina, I, Stella, G, Kissel, H, Besmer, P

EMBO J 1998
9341198 Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

Linnekin, D, Mou, S, DeBerry, CS

J Biol Chem 1997
17213284 Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells

Kapur, R, Samayawardhena, LA, Craig, AW

Blood 2007
9788619 Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1

Linnekin, D, Krystal, GW, Litz, J, DeBerry, CS

Cancer Res 1998
15024050 Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development

Ehlers, I, Moore, MA, Sommer, G, Manova, K, Corbacioglu, S, Waskow, C, Kissel, H, Besmer, P, Rodewald, HR, Tucker, CM, Berrozpe, G, Agosti, V

J Exp Med 2004
11435302 Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

Lowell, C, Metcalfe, DD, DeBerry, C, O'Laughlin-Bunner, B, Taylor, ML, Linnekin, D, Shivakrupa, ML, Radosevic, N, Zhou, M

Blood 2001
10523831 Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

Pontén, E, Carlberg, M, Hermanson, M, Blume-Jensen, P, Lennartsson, J, Rönnstrand, L

Oncogene 1999
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