Fusion of Glut4 Vesicle with the Plasma Membrane

Stable Identifier
R-MMU-1449573
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Fusion of Glut4 Vesicle with the Plasma Membrane

After docking at the membrane Vamp2 on the vesicle interacts with Syntaxin-4 and Snap23 on the plasma membrane to catalyze fusion of the vesicle with the plasma membrane. Stxbp3 (Munc18c) bound to Stx4 prevents fusion until Stxbp3 is phosphorylated.

Literature References
PubMed ID Title Journal Year
19074577 A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle

Schertzer, JD, Antonescu, CN, Bilan, PJ, Jain, S, Huang, X, Liu, Z, Bonen, A, Klip, A

Endocrinology 2009
17515613 Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation

Yoshizaki, T, Imamura, T, Babendure, JL, Lu, JC, Sonoda, N, Olefsky, JM

Mol Cell Biol 2007
10713150 Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2

Kawanishi, M, Tamori, Y, Okazawa, H, Araki, S, Shinoda, H, Kasuga, M

J Biol Chem 2000
21127070 Myo1c regulates glucose uptake in mouse skeletal muscle

Toyoda, T, An, D, Witczak, CA, Koh, HJ, Hirshman, MF, Fujii, N, Goodyear, LJ

J Biol Chem 2011
19046570 CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes

Yip, MF, Ramm, G, Larance, M, Hoehn, KL, Wagner, MC, Guilhaus, M, James, DE

Cell Metab 2008
14562105 Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking

Bogan, JS, Hendon, N, McKee, AE, Tsao, TS, Lodish, HF

Nature 2003
15169906 Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway

Bose, A, Robida, S, Furcinitti, PS, Chawla, A, Fogarty, K, Corvera, S, Czech, MP

Mol Cell Biol 2004
17202135 The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes

Yu, C, Cresswell, J, Löffler, MG, Bogan, JS

J Biol Chem 2007
21444687 Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, JL, Oh, E, Ramalingam, L, Kalwat, MA, Tagliabracci, VS, Tackett, L, Elmendorf, JS, Thurmond, DC

J. Cell Biol. 2011
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