Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Timp2 [extracellular region]
Stable Identifier
R-MMU-1454879
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
TIMP2, P25785
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Mus musculus)
Degradation of the extracellular matrix (Mus musculus)
Activation of Matrix Metalloproteinases (Mus musculus)
Autocatalytic activation of bound proMMP2 (Mus musculus)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
MMP14:TIMP:MMP2 [plasma membrane] (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Initial activation of proMMP2 by MMP14 (Mus musculus)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
MMP14:TIMP2:proMMP2 [plasma membrane] (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
MMP14:TIMP2 binds proMMP2 (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
MMP14:TIMP2:proMMP2 [plasma membrane] (Mus musculus)
MMP14:TIMP2 [plasma membrane] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Neutrophil degranulation (Mus musculus)
Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)
Ficolin-rich granule lumen proteins [extracellular region] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Exocytosis of specific granule lumen proteins (Mus musculus)
Specific granule lumen proteins [extracellular region] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Exocytosis of tertiary granule lumen proteins (Mus musculus)
Tertiary granule lumen proteins [extracellular region] (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGFBR3 (Mus musculus)
TGFBR3 PTM regulation (Mus musculus)
TGFBR3_mem cleavage by MMPs (Mus musculus)
Timp2 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P25785
Gene Names
Timp2
Reference Genes
ENSEMBL:ENSMUSG00000017466
UCSC:P25785 Timp2
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Mus musculus)
Specific granule lumen proteins [extracellular region] (Mus musculus)
Tertiary granule lumen proteins [extracellular region] (Mus musculus)
as an input of
MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)
as a component of
MMP14:TIMP2 [plasma membrane] (Mus musculus)
This entity regulates
Negatively
TGFBR3_mem cleavage by MMPs
(Mus musculus)
Other forms of this molecule
Timp2 [ficolin-1-rich granule lumen]
Timp2 [specific granule lumen]
Timp2 [tertiary granule lumen]
Inferred From
TIMP2 [extracellular region]
(Homo sapiens)
Cross References
PRO
P25785
MGI
98753
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text