RalA Hydrolyzes GTP

Stable Identifier
R-MMU-1458501
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytoplasmic vesicle membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RalA Hydrolyzes GTP
Rala binds guanine nucleotides and hydrolyzes bound GTP to yield GDP and phosphate (Chen et al. 2007, Chen et al. 2011). The GTPase activity of Rala is regulated by interaction with GTPase-activating proteins(GAPs) (Chen et al. 2011). Rgc1 and Rgc2 are GAPs that activate Rala. Insulin signaling activates Akt, which phosphorylates Rgc2, inactivating the GAP activity of Rgc1:Rgc2 and allowing Rala:GTP to accumulate.
Literature References
PubMed ID Title Journal Year
21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Cheng, A, Yu, G, Decker, S, Xiong, T, Chen, XW, Saltiel, AR, Leto, D

Mol Biol Cell 2011
17765682 Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c

Wang, Q, Chiang, SH, Chen, XW, Saltiel, AR, Leto, D

Dev Cell 2007
Participants
Input
Output
Catalyst Activity

GTPase activity of GGC-Rala:GTP [cytoplasmic vesicle membrane]

Physical Entity
GGC-Rala:GTP [cytoplasmic vesicle membrane] (Mus musculus)
Activity
GTPase activity (GO:0003924)
This event is regulated
Positively by
Regulator
Rgc1:Rgc2 [cytosol] (Mus musculus)
Orthologous Events
RALA hydrolyzes GTP (Homo sapiens)
Authored
May, B  (2011-07-17)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-21)
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