Akt2 Phosphorylates Rgc2

Stable Identifier
R-MMU-1458507
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
Synonyms
Akt2 Phosphorylates Ralgapa2
ReviewStatus
5/5
General
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Akt2 Phosphorylates Rgc2
Akt2 (Pkb-beta) phosphorylates Rbc2 (Ralgapa2) on serine-486, serine-696, and threonine-715 in response to insulin (Chen et al. 2011). The phosphorylation inhibits activation of RalA GTPase and allows RalA:GTP to accumulate.
Literature References
PubMed ID Title Journal Year
21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Cheng, A, Yu, G, Decker, S, Xiong, T, Chen, XW, Saltiel, AR, Leto, D

Mol Biol Cell 2011
19372382 Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

Gonzalez, E, McGraw, TE

Proc Natl Acad Sci U S A 2009
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T309, S474-Akt2 [plasma membrane]

Physical Entity
p-T309, S474-Akt2 [plasma membrane] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-AKT2 phosphorylates RGC2 (Homo sapiens)
Authored
May, B  (2011-07-17)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-21)
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