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MIB2 [cytosol]
Stable Identifier
R-MMU-1472879
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q8R516
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
MIB2 binds CFLAR (Mus musculus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 binds CYLD (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2:CYLD:UBE2D2 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)
MIB2 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 ubiquitinates CFLAR (Mus musculus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2:CYLD:UBE2D2 [cytosol] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)
MIB2 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
MIB2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8R516
Reference Genes
BioGPS Gene:76580
ENSEMBL:ENSMUSG00000029060
ENSEMBL:ENSMUSG00000029060.18
KEGG Gene (Mus musculus):76580
Monarch:76580
NCBI Gene:76580
UCSC:Q8R516
Reference Transcript
RefSeq:NM_001256108.2
RefSeq:NM_145124.3
Other Identifiers
10519151
112999_at
1424862_s_at
17433826
4411232
4468236
4492080
4521770
4568895
4612245
4631635
4631933
4670351
4672083
4713045
4753902
4761901
4765076
4807102
4830881
4844155
5022957
5043183
5085258
5121780
5162947
5202999
5208718
5211660
5222065
5346716
5428952
5498808
5512099
76580
A_52_P384508
A_55_P1963900
GO:0000151
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0007219
GO:0008092
GO:0008270
GO:0016567
GO:0016740
GO:0023052
GO:0031410
GO:0036211
GO:0043226
GO:0046872
GO:0061630
GO:0140096
ILMN_2769393
mMC010990
Participates
as an input of
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)
MIB2 binds CFLAR (Mus musculus)
MIB2 binds CYLD (Mus musculus)
as a component of
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Mus musculus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Mus musculus)
MIB2:CYLD:UBE2D2 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Mus musculus)
as an output of
MIB2 ubiquitinates CFLAR (Mus musculus)
MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Inferred From
MIB2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_660106.2
,
NP_001243037.2
Ensembl
ENSMUST00000103176
,
ENSMUSP00000099465
,
ENSMUSG00000029060
PRO
Q8R516
MGI
2679684
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