Reactome | IGHE [extracellular region]

IGHE [extracellular region]

Stable Identifier

R-MMU-1478806

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IGHE, P06336

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - Allergen dependent IgE bound FCERI aggregation (Mus musculus)
      - FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - FCERI mediated Ca+2 mobilization (Mus musculus)
      - Phosphorylation of TEC kinases by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Phosphorylation of SHC by SYK kinase (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - FCERI mediated NF-kB activation (Mus musculus)
      - Phosphorylation of PKC-theta (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - IgE binds FCERI (Mus musculus)
      - FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - IgE binds omalizumab (Mus musculus)
      - IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - IgE:omalizumab [extracellular region] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - Phosphorylation of LAT by p-SYK (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - Phosphorylation of beta and gamma subunits by LYN (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        IgE Heavy Chain [extracellular region] (Mus musculus)
        
        IGHE [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P06336

Gene Names

IGHE

Reference Genes

ENSEMBL:ENSMUSG00000087642

Participates

as a component of

IgE Heavy Chain [extracellular region] (Mus musculus)

Inferred From

IGHE [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000211891

PRO

P06336

MGI

2685746

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