Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-Cdk1 [cytosol]
Stable Identifier
R-MMU-157415
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-T161-CDK1, P11440
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Nuclear Envelope (NE) Reassembly (Mus musculus)
Initiation of Nuclear Envelope (NE) Reformation (Mus musculus)
CDK1 phosphorylates LBR (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Mitotic Prometaphase (Mus musculus)
Resolution of Sister Chromatid Cohesion (Mus musculus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Mitotic Prophase (Mus musculus)
Nuclear Envelope Breakdown (Mus musculus)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Mus musculus)
CDK1:CCNB phosphorylates NEK9 (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Nuclear Pore Complex (NPC) Disassembly (Mus musculus)
CDK1 phosphorylates NUP98 (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CRS kinase [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)
cytoplasmic Cyclin B1:Cdc2 complexes [cytosol] (Mus musculus)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Regulation of PLK1 Activity at G2/M Transition (Mus musculus)
CDK1 phosphorylates BORA (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Mus musculus)
Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)
Mitotic kinase [cytosol] (Mus musculus)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Cyclin B (Mus musculus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
Association of Cyclin A with the APC/C (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Degradation multiubiquitinated Cyclin A (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
MAPK3 (ERK1) activation (Mus musculus)
Inactivation of MAP2K1 by CDK1 (Mus musculus)
phospho-Cdk1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P11440 Cdk1
Gene Names
Cdk1, Cdc2, Cdc2a, Cdkn1
Chain
chain:1-297
Reference Genes
BioGPS Gene:12534 Cdk1
ENSEMBL:ENSMUSG00000019942 Cdk1
KEGG Gene (Mus musculus):12534 Cdk1
Monarch:12534 Cdk1
NCBI Gene:12534 Cdk1
UCSC:P11440 Cdk1
Reference Transcript
RefSeq:NM_007659.3 Cdk1
Other Identifiers
100128_at
10369815
12534
1448314_at
17241692
4472993
4588721
4720947
4881487
4934166
5093482
5121588
5251273
5275259
5480188
5511184
5551219
5556695
A_52_P339954
A_55_P2016647
A_55_P2016652
A_55_P2048588
GE1469937
GE33489
GO:0003674
GO:0004672
GO:0005524
GO:0006464
GO:0006468
GO:0008150
GO:0016301
GO:0043167
ILMN_2657844
ILMN_2698252
ILMN_2961747
Msa.18569.0_s_at
mMC016053
u58633_s_at
Participates
as an output of
Degradation multiubiquitinated Cyclin A (Mus musculus)
Degradation of multiubiquitinated Cyclin B (Mus musculus)
as a component of
CCNB1:p-T161-CDK1 [cytosol] (Mus musculus)
CCNB2:p-T161-CDK1 [cytosol] (Mus musculus)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Mus musculus)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Mus musculus)
Other forms of this molecule
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [nucleoplasm]
Cdk1 [cytosol]
Cdk1 [nucleoplasm]
Cdk1 [endoplasmic reticulum membrane]
Inferred From
p-T161-CDK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 161 (in Homo sapiens)
Coordinate
161
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_031685.2
IntEnz
2.7.11.23
ZINC - Substances
CDK1_MOUSE
ZINC - Biogenic
CDK1_MOUSE
ZINC target
P11440
Ensembl
ENSMUST00000119827
,
ENSMUST00000020099
,
ENSMUSP00000113184
,
ENSMUSG00000019942
,
ENSMUSP00000020099
PRO
P11440
ZINC - Predictions - Purchasable
CDK1_MOUSE
MGI
88351
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.623
4
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.623
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.623
3
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
0.623
4
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.623
4
UniProt:P33552 CKS2
0.623
4
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.623
4
UniProt:P20263
1
Pou5f1 [nucleoplasm]
(R-MMU-452472)
0.61
4
UniProt:Q61457
2
Ccne1 [nucleoplasm]
(R-MMU-68363)
Ccne1 [cytosol]
(R-MMU-157443)
0.589
3
UniProt:Q99640 PKMYT1
3
PKMYT1 [nucleoplasm]
(R-HSA-74386)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [cytosol]
(R-HSA-157457)
0.564
3
UniProt:Q9UJX3 ANAPC7
2
ANAPC7 [cytosol]
(R-HSA-174242)
ANAPC7 [nucleoplasm]
(R-HSA-174204)
0.499
2
UniProt:Q8IVT2 MISP
0.499
2
UniProt:P22674 CCNO
0.499
2
UniProt:Q14674 ESPL1
4
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.499
2
UniProt:O43175 PHGDH
1
PHGDH [cytosol]
(R-HSA-977340)
0.499
2
UniProt:Q14204 DYNC1H1
3
DYNC1H1 [azurophil granule lumen]
(R-HSA-6799155)
DYNC1H1 [extracellular region]
(R-HSA-6806223)
DYNC1H1 [cytosol]
(R-HSA-380285)
0.499
2
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.499
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text