Reactome | Gja1 [plasma membrane]

Gja1 [plasma membrane]

Stable Identifier

R-MMU-158058

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

GJA1, P23242

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Gap junction trafficking and regulation (Mus musculus)
    - Gap junction trafficking (Mus musculus)
      - Gap junction degradation (Mus musculus)
        
        Formation of annular gap junctions (Mus musculus)
        
        Dab2 is recruited to the junctional plaques (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        gap junction plaque [plasma membrane] (Mus musculus)
        
        Junctional channel [plasma membrane] (Mus musculus)
        
        Hemi-channels [plasma membrane] (Mus musculus)
        
        Connexin 43 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        gap junction plaque [plasma membrane] (Mus musculus)
        
        Junctional channel [plasma membrane] (Mus musculus)
        
        Hemi-channels [plasma membrane] (Mus musculus)
        
        Connexin 43 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
        
        Dynamin is recruited to the gap junction plaque (Mus musculus)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        gap junction plaque [plasma membrane] (Mus musculus)
        
        Junctional channel [plasma membrane] (Mus musculus)
        
        Hemi-channels [plasma membrane] (Mus musculus)
        
        Connexin 43 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        gap junction plaque [plasma membrane] (Mus musculus)
        
        Junctional channel [plasma membrane] (Mus musculus)
        
        Hemi-channels [plasma membrane] (Mus musculus)
        
        Connexin 43 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
        
        Internalization of gap junction plaques (Mus musculus)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        gap junction plaque [plasma membrane] (Mus musculus)
        
        Junctional channel [plasma membrane] (Mus musculus)
        
        Hemi-channels [plasma membrane] (Mus musculus)
        
        Connexin 43 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
    - Regulation of gap junction activity (Mus musculus)
      - Phosphorylation of Cx43 by c-src (Mus musculus)
        
        Cx43:ZO-1:c-src gap junction [plasma membrane] (Mus musculus)
        
        Cx43:ZO-1:c-src hemi-channel [plasma membrane] (Mus musculus)
        
        6xGJA1:6xTJP1 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
      - c-src associates with Cx43 in gap junctions (Mus musculus)
        
        Cx43 :ZO-1 gap junction [plasma membrane] (Mus musculus)
        
        6xGJA1:6xTJP1 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)
        
        Cx43:ZO-1:c-src gap junction [plasma membrane] (Mus musculus)
        
        Cx43:ZO-1:c-src hemi-channel [plasma membrane] (Mus musculus)
        
        6xGJA1:6xTJP1 hemi-channel [plasma membrane] (Mus musculus)
        
        Gja1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P23242

Gene Names

Gja1

Reference Genes

BioGPS Gene:14609 Gja1

ENSEMBL:ENSMUSG00000050953

ENSEMBL:ENSMUSG00000050953.11 Gja1

KEGG Gene (Mus musculus):14609 Gja1

Monarch:14609 Gja1

NCBI Gene:14609 Gja1

UCSC:P23242 Gja1

Reference Transcript

RefSeq:NM_010288.3 Gja1

Other Identifiers

100064_f_at

100065_r_at

10363173

1415800_at

1415801_at

1437992_x_at

1438650_x_at

1438945_x_at

1438973_x_at

14609

17233347

4594714

4995103

5112828

5161332

5287365

5436831

5599624

A_52_P174915

A_55_P2741907

A_55_P2741911

GE35467

GO:0000132

GO:0000278

GO:0001649

GO:0001701

GO:0001764

GO:0001937

GO:0001947

GO:0002069

GO:0002088

GO:0002376

GO:0002544

GO:0002931

GO:0003013

GO:0003014

GO:0003104

GO:0003158

GO:0003294

GO:0003347

GO:0005102

GO:0005215

GO:0005243

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005769

GO:0005770

GO:0005771

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005882

GO:0005886

GO:0005911

GO:0005916

GO:0005921

GO:0005922

GO:0006954

GO:0007010

GO:0007154

GO:0007163

GO:0007165

GO:0007204

GO:0007267

GO:0007283

GO:0007507

GO:0007512

GO:0008013

GO:0008016

GO:0008092

GO:0008104

GO:0008285

GO:0008584

GO:0009268

GO:0009749

GO:0010232

GO:0010628

GO:0010629

GO:0010643

GO:0010644

GO:0010649

GO:0010652

GO:0012501

GO:0014047

GO:0014704

GO:0015075

GO:0015562

GO:0015631

GO:0015867

GO:0016020

GO:0016324

GO:0016328

GO:0017124

GO:0019904

GO:0022414

GO:0022857

GO:0023052

GO:0030054

GO:0030154

GO:0030163

GO:0030165

GO:0030308

GO:0030500

GO:0031410

GO:0032024

GO:0032277

GO:0032355

GO:0032496

GO:0032526

GO:0032991

GO:0034220

GO:0034330

GO:0034405

GO:0034634

GO:0034775

GO:0035050

GO:0035437

GO:0042098

GO:0042110

GO:0042311

GO:0042733

GO:0042908

GO:0042981

GO:0043014

GO:0043226

GO:0043231

GO:0043292

GO:0043403

GO:0043434

GO:0044291

GO:0045121

GO:0045216

GO:0045732

GO:0045836

GO:0045844

GO:0045907

GO:0046697

GO:0046849

GO:0046850

GO:0048487

GO:0048514

GO:0048812

GO:0048856

GO:0048870

GO:0050886

GO:0051924

GO:0055077

GO:0055085

GO:0060044

GO:0060156

GO:0060307

GO:0060312

GO:0060348

GO:0060371

GO:0060373

GO:0061337

GO:0070160

GO:0070161

GO:0071253

GO:0071260

GO:0071374

GO:0071467

GO:0086064

GO:0086075

GO:0090162

GO:0097110

GO:0097402

GO:0097718

GO:0099111

GO:0110053

GO:0120162

GO:0140013

GO:0140115

GO:1901164

GO:1903763

GO:1904446

GO:1904646

GO:1904707

GO:1905332

GO:1905772

GO:1905867

GO:1990782

GO:2000279

GO:2000648

GO:2000810

GO:2000987

ILMN_1244291

mMC017599

x61576_s_at

Participates

as a candidate of

as a component of

Other forms of this molecule

Gja1 [Golgi membrane]

Gja1 [endoplasmic reticulum membrane]

Gja1 [lysosomal membrane]

phospho-Gja1 [plasma membrane]

Gja1 [Golgi-associated vesicle membrane]

Inferred From

GJA1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034418.1

Ensembl

ENSMUST00000068581, ENSMUST00000220069, ENSMUSP00000064536, ENSMUSG00000050953, ENSMUSP00000151620

PRO

P23242

MGI

95713

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39447	3	Tjp1 [plasma membrane] (R-MMU-3209844) Tjp1 [plasma membrane] (R-MMU-3209845) Tjp1 [cytosol] (R-MMU-532659)	0.695	4
UniProt:Q63664	1	Kcnj8 [plasma membrane] (R-RNO-265575)	0.61	4
UniProt:P16054	2	phospho-p-T566,T710,S729-PRKCE [plasma membrane] (R-MMU-198260) PRKCE [cytosol] (R-MMU-58202)	0.564	3
UniProt:P28867	11	PRKCD(1-676) [nucleoplasm] (R-MMU-450606) PRKCD [cytosol] (R-MMU-58200) PRKCD(1-329) [cytosol] (R-MMU-212547) PRKCD(330-676) [cytosol] (R-MMU-212551) phospho-p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-MMU-198294) phospho-p-T507,S645,S664-PRKCD [cytosol] (R-MMU-5218734) phospho-p-T507-PRKCD [cytosol] (R-MMU-5218746) PRKCD(330-676) [azurophil granule lumen] (R-MMU-6799221) PRKCD(1-329) [azurophil granule lumen] (R-MMU-6799219) PRKCD(1-329) [extracellular region] (R-MMU-6806226) PRKCD(330-676) [extracellular region] (R-MMU-6806199)	0.556	4
UniProt:P68254 Ywhaq	1	14-3-3 theta [cytosol] (R-MMU-1445117)	0.537	3
UniProt:P11688	2	ITGA5 [plasma membrane] (R-MMU-9857636) ITGA5(42-894) [plasma membrane] (R-MMU-202735)	0.528	2
UniProt:Q8C0J2 Atg16l1	1	Atg16l1 [cytosol] (R-MMU-5682691)	0.524	2
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.499	3
UniProt:Q6NZM9 Hdac4	4	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-MMU-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-MMU-4616016) Hdac4 [nucleoplasm] (R-MMU-9008337) HDAC4 [nucleoplasm] (R-MMU-351581)	0.499	2
UniProt:Q8CDJ3	3	Atg14 [phagophore assembly site membrane] (R-MMU-5682389) Atg14 [endoplasmic reticulum membrane] (R-MMU-5679263) Atg14 [cytosol] (R-MMU-5668893)	0.499	2
UniProt:Q6PF93	2	Pik3c3 [phagocytic vesicle membrane] (R-MMU-6798182) Pik3c3 [cytosol] (R-MMU-188011)	0.499	4
UniProt:Q8VD65	2	PIK3R4 [phagocytic vesicle membrane] (R-MMU-6798171) PIK3R4 [cytosol] (R-MMU-188010)	0.499	3
UniProt:Q9CZX0 ELP3			0.463	2
UniProt:Q4VAE3 TMM65			0.463	2

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