Reactome | Ptpn11 [cytosol]

Ptpn11 [cytosol]

Stable Identifier

R-MMU-162563

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PTPN11, P35235

Locations in the PathwayBrowser for interactor UniProt:Q80ZE3"

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External Reference Information

External Reference

UniProt:P35235 Ptpn11

Gene Names

Ptpn11

Chain

initiator methionine:1, chain:2-593

Reference Genes

BioGPS Gene:19247 Ptpn11

ENSEMBL:ENSMUSG00000043733 Ptpn11

KEGG Gene (Mus musculus):19247 Ptpn11

Monarch:19247 Ptpn11

NCBI Gene:19247 Ptpn11

UCSC:P35235 Ptpn11

Reference Transcript

Other Identifiers

102874_at

10533285

114636_at

1421196_at

1427699_a_at

1451225_at

17452161

19247

4322855

4329015

4478855

4507916

4518283

4524274

4566118

4618693

4664661

4849125

4891955

5199118

5200785

5319892

5406406

5431131

5469518

5614591

A_51_P173622

A_52_P211393

A_52_P641185

GE35963

GO:0003674

GO:0004725

GO:0006464

GO:0006470

GO:0008150

GO:0016311

GO:0016791

ILMN_1245874

ILMN_2681329

ILMN_2723559

ILMN_2743723

ILMN_3001598

d84372_s_at

mMC000988

mMC014708

mMC023487

mMR027502

Participates

as an input of

as a component of

as a member of

PTPN6,PTPN11 [cytosol] (Mus musculus)

This entity regulates

Negatively

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)

Other forms of this molecule

p-Y546,Y584-Shp2 [cytosol]

Ptpn11 [cytosol]

Ptpn11 [nucleoplasm]

phospho-Ptpn11 [cytosol]

Inferred From

PTPN11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001103462.1, NP_035332.1

Ensembl

ENSMUSP00000098333, ENSMUSP00000058757, ENSMUSG00000043733, ENSMUST00000054547, ENSMUST00000100770

PRO

P35235

MGI

99511

PDB

1AYD, 1AYB, 1AYA, 1AYC

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.809	7
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	4
UniProt:Q60631 Grb2	3	Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-74686) Grb2 [cytosol] (R-MMU-443287)	0.59	3
UniProt:P97484 LIRB3			0.589	2
UniProt:P30999	1	Ctnnd1 [plasma membrane] (R-MMU-418996)	0.544	3
UniProt:Q01097 Grin2b	7	phospho-Grin2b [plasma membrane] (R-MMU-3928477) p-Nr2b [plasma membrane] (R-MMU-3928470) Grin2b [endoplasmic reticulum membrane] (R-MMU-9610361) Grin2b [plasma membrane] (R-MMU-3928478) Grin2b [transport vesicle membrane] (R-MMU-9610571) Grin2b [endoplasmic reticulum membrane] (R-MMU-9609765) Grin2b [plasma membrane] (R-MMU-419558)	0.527	2
UniProt:P10721 KIT	111	KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT C443Y [plasma membrane] (R-HSA-9680045) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617) p7Y-KIT N822D [plasma membrane] (R-HSA-9669613) p7Y-KIT N822S [plasma membrane] (R-HSA-9669614) p-7Y KIT V654E [plasma membrane] (R-HSA-9669615) p7Y-KIT N822I [plasma membrane] (R-HSA-9669608) p7Y-KIT D816N [plasma membrane] (R-HSA-9669611) p7Y-KIT A829P [plasma membrane] (R-HSA-9669605) p7Y-KIT D816H [plasma membrane] (R-HSA-9669606) p6Y-KIT Y823C [plasma membrane] (R-HSA-9669607) p7Y-KIT K642Q [plasma membrane] (R-HSA-9669601) p6Y-KIT Y823N [plasma membrane] (R-HSA-9669597) p7Y-KIT D816A [plasma membrane] (R-HSA-9669629) p7Y-KIT N822H [plasma membrane] (R-HSA-9669598) p7Y-KIT D816F [plasma membrane] (R-HSA-9671513) p-7Y KIT V654A [plasma membrane] (R-HSA-9669593) p7Y-KIT N822T [plasma membrane] (R-HSA-9669622) p7Y-KIT D816E [plasma membrane] (R-HSA-9671510) p7Y-KIT D816Y [plasma membrane] (R-HSA-9669623) p7Y-KIT N822Y [plasma membrane] (R-HSA-9669619) p7Y-KIT V559D [plasma membrane] (R-HSA-9669620) p7Y-KIT K550I P551_V555del [plasma membrane] (R-HSA-9669602) p-7Y KIT W557_K558del [plasma membrane] (R-HSA-9670352) p-5Y KIT V560_L576del [plasma membrane] (R-HSA-9670348) p7Y-KIT L576P [plasma membrane] (R-HSA-9669616) p7Y-KIT V559_V560del [plasma membrane] (R-HSA-9669618) p7Y-KIT P551_V555del [plasma membrane] (R-HSA-9669621) p7Y-KIT V560G [plasma membrane] (R-HSA-9669610) p7Y-KIT K550_K558del [plasma membrane] (R-HSA-9669624) p7Y-KIT V560E [plasma membrane] (R-HSA-9669603) p7Y-KIT V560D [plasma membrane] (R-HSA-9669626) p7Y-KIT V559A [plasma membrane] (R-HSA-9669625) p7Y-KIT V559I [plasma membrane] (R-HSA-9669609) p7Y-KIT W557R [plasma membrane] (R-HSA-9669627) p7Y-KIT V559G [plasma membrane] (R-HSA-9669600) p7Y-KIT W557G [plasma membrane] (R-HSA-9669604) p7Y-KIT K509I [plasma membrane] (R-HSA-9680180) p7Y-KIT A502_Y503dup [plasma membrane] (R-HSA-9680120) p7Y-KIT S476I [plasma membrane] (R-HSA-9680156) p7Y-KIT C443Y [plasma membrane] (R-HSA-9680138) p7Y-KIT D419A [plasma membrane] (R-HSA-9680129) p7Y-KIT T417-D419delinsY [plasma membrane] (R-HSA-9680165) p7Y-KIT D419H [plasma membrane] (R-HSA-9680132) p7Y-KIT S501_A502dup [plasma membrane] (R-HSA-9680161) p7Y-KIT D419del [plasma membrane] (R-HSA-9680127) p7Y-KIT N505_F508dup [plasma membrane] (R-HSA-9680159) p7Y-KIT D419N [plasma membrane] (R-HSA-9680134) p7Y-KIT C443S [plasma membrane] (R-HSA-9680137) p7Y-KIT S476N [plasma membrane] (R-HSA-9680158) p7Y-KIT D419G [plasma membrane] (R-HSA-9680130) KIT A829P [plasma membrane] (R-HSA-9669426) KIT N822D [plasma membrane] (R-HSA-9669447) KIT V654E [plasma membrane] (R-HSA-9669576) KIT W557R [plasma membrane] (R-HSA-9669581) KIT W557G [plasma membrane] (R-HSA-9669578) KIT V559A [plasma membrane] (R-HSA-9669547) KIT K550I P551_V555del [plasma membrane] (R-HSA-9669444) KIT L576P [plasma membrane] (R-HSA-9669446) KIT V559_V560del [plasma membrane] (R-HSA-9669561) KIT P551_V555del [plasma membrane] (R-HSA-9669433) KIT V559I [plasma membrane] (R-HSA-9669557) KIT K550_K558del [plasma membrane] (R-HSA-9669461) KIT V559G [plasma membrane] (R-HSA-9669554) KIT V559D [plasma membrane] (R-HSA-9669551) KIT W557_K558del [plasma membrane] (R-HSA-9670343) KIT Y823D [plasma membrane] (R-HSA-9669587) KIT D816V [plasma membrane] (R-HSA-9669452) KIT N822Y [plasma membrane] (R-HSA-9669454) KIT T670I [plasma membrane] (R-HSA-9669545) KIT D820E [plasma membrane] (R-HSA-9669449) KIT V654A [plasma membrane] (R-HSA-9669572) KIT D816H [plasma membrane] (R-HSA-9669445) KIT K642E [plasma membrane] (R-HSA-9669443) KIT V560D [plasma membrane] (R-HSA-9669564) KIT N822H [plasma membrane] (R-HSA-9669437) KIT A502_Y503dup [plasma membrane] (R-HSA-9680030) KIT N822K [plasma membrane] (R-HSA-9669464) KIT D816Y [plasma membrane] (R-HSA-9669435) KIT D820A [plasma membrane] (R-HSA-9669460) KIT N822T [plasma membrane] (R-HSA-9669463) KIT D816F [plasma membrane] (R-HSA-9669457) KIT K642Q [plasma membrane] (R-HSA-9669468) KIT D816E [plasma membrane] (R-HSA-9669436) KIT N822I [plasma membrane] (R-HSA-9669453) KIT V560E [plasma membrane] (R-HSA-9669566) KIT N822S [plasma membrane] (R-HSA-9669466) KIT D816N [plasma membrane] (R-HSA-9669451) KIT D816A [plasma membrane] (R-HSA-9669428) KIT V560G [plasma membrane] (R-HSA-9669569) p-8Y-KIT [plasma membrane] (R-HSA-1472116) p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.524	2
UniProt:P28776	1	Ido1 [cytosol] (R-MMU-198574)	0.499	5
UniProt:Q8K4V6 Q8K4V6			0.499	3
UniProt:P15209 Ntrk2	4	Ntrk2 [plasma membrane] (R-MMU-9025038) phospho-Ntrk2 [plasma membrane] (R-MMU-9026475) p-5Y-Ntrk2 [plasma membrane] (R-MMU-9030410) p-5Y,S478-Ntrk2 [plasma membrane] (R-MMU-9033310)	0.499	2
UniProt:Q80ZE3	3	Siglec10 [plasma membrane] (R-MMU-197707) Siglec10 [plasma membrane] (R-MMU-197709) Siglec10 [plasma membrane] (R-MMU-2326826)	0.462	4
UniProt:Q6Q899 Ddx58	4	Rig-I [cytosol] (R-MMU-936468) Ddx58 [cytosol] (R-MMU-6782999) Ddx58 [cytosol] (R-MMU-168917) Ddx58 [cytosol] (R-MMU-918191)	0.462	4
UniProt:O35718 Socs3	1	Socs3 [cytosol] (R-MMU-1169197)	0.462	2

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