Reactome | XPO1 [cytosol]

XPO1 [cytosol]

Stable Identifier

R-MMU-165539

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q6P5F9

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        XPO1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6P5F9

Reference Genes

BioGPS Gene:103573

dbSNP Gene:103573

ENSEMBL:ENSMUSG00000020290

KEGG Gene (Mus musculus):103573

Monarch:103573

NCBI Gene:103573

UCSC:Q6P5F9

Reference Transcript

Other Identifiers

103573

10374590

1418442_at

1418443_at

1448070_at

17247695

216139

216140

3GJX

3NBY

3NBZ

3NC0

3NC1

4390438

4435797

4452783

4591119

4597725

4610899

4617081

4639105

4729603

4798573

4800305

4830684

4862183

4940576

4940931

4979940

4985790

5065885

5135169

5264477

5276209

5351774

5422937

5436749

5454853

5501504

5508842

5510025

5513272

5541295

5545484

5565613

5584169

5610418

94131_at

94228_at

A2AKT6

A_51_P336635

A_52_P633543

A_55_P2089942

AA154817_at

aa267296_s_at

aa545124_at

aa545124_g_at

AAH62912

BC062912

CCDS24475

ENSMUSG00000020290

ENSMUSP00000020538

ENSMUSP00000099933

ENSMUSP00000099934

ENSMUSP00000105178

ENSMUST00000020538

ENSMUST00000102869

ENSMUST00000102870

ENSMUST00000109551

EntrezGene:103573

EntrezGene:Xpo1

GE127911

GO:0000054

GO:0000055

GO:0000056

GO:0000122

GO:0000776

GO:0003674

GO:0003723

GO:0005049

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005642

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006611

GO:0006810

GO:0006886

GO:0006913

GO:0007010

GO:0007049

GO:0008150

GO:0008536

GO:0009056

GO:0009058

GO:0010824

GO:0015030

GO:0015031

GO:0019899

GO:0019904

GO:0031965

GO:0032991

GO:0034504

GO:0034641

GO:0042176

GO:0042254

GO:0042493

GO:0043226

GO:0043231

GO:0046825

GO:0051028

GO:1990904

ILMN_2481528

ILMN_2490008

ILMN_3123321

IPR001494

IPR011989

IPR013598

IPR014877

IPR016024

IPR040485

IPR041123

IPR041235

MGI:2144013

mMC006183

mMR028377

NM_001035226

NM_134014

NP_001030303

NP_598775

PF03810

PF08389

PF08767

PF18777

PF18784

PF18787

SM00913

SM01102

uc057kko.1

UPI000022467D

XM_006514430

XM_017314208

XM_017314209

XM_017314210

XP_006514493

XP_017169697

XP_017169698

XP_017169699

Xpo1

Xpo1-201

Xpo1-202

Xpo1-203

Xpo1-204

Participant Of

hasComponent

Other forms of this molecule

XPO1 [nucleoplasm]

Inferred From

XPO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006514493.1, NP_001030303.1, NP_598775.2

PRO

Q6P5F9

PDB

3NBY, 3NBZ, 3GJX, 3NC0, 3NC1

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.676	3
UniProt:P61925 IPKA			0.645	4
UniProt:O95149 SNUPN	1	SNUPN [cytosol] (R-HSA-191857)	0.59	2
UniProt:Q13523 PRP4B			0.527	2
UniProt:Q6GNU1 AR1BB			0.525	2
UniProt:B7ZR20 B7ZR20			0.525	2
UniProt:Q91855 Q91855			0.525	2
UniProt:Q3B8L5 Q3B8L5			0.525	2
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.499	4