Reactome | Ppp2r1a [nucleoplasm]

Ppp2r1a [nucleoplasm]

Stable Identifier

R-MMU-165968

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PPP2R1A, Q76MZ3

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Expression and Degradation (Mus musculus)
        
        Regulation of TP53 Degradation (Mus musculus)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)
        
        PP2A-PPP2R5C [nucleoplasm] (Mus musculus)
        
        PP2A-subunit A [nucleoplasm] (Mus musculus)
        
        Ppp2r1a [nucleoplasm] (Mus musculus)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Mus musculus)
        
        PP2A-PPP2R5C [nucleoplasm] (Mus musculus)
        
        PP2A-subunit A [nucleoplasm] (Mus musculus)
        
        Ppp2r1a [nucleoplasm] (Mus musculus)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)
        
        PP2A-PPP2R5C [nucleoplasm] (Mus musculus)
        
        PP2A-subunit A [nucleoplasm] (Mus musculus)
        
        Ppp2r1a [nucleoplasm] (Mus musculus)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Mus musculus)
        
        PP2A-PPP2R5C [nucleoplasm] (Mus musculus)
        
        PP2A-subunit A [nucleoplasm] (Mus musculus)
        
        Ppp2r1a [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q76MZ3 Ppp2r1a

Gene Names

Ppp2r1a

Chain

initiator methionine:, chain:2-589

Reference Genes

BioGPS Gene:51792 Ppp2r1a

KEGG:mmu:51792 Ppp2r1a

Monarch:51792 Ppp2r1a

NCBI Gene:51792 Ppp2r1a

UCSC:Q76MZ3 Ppp2r1a

Reference Transcript

RefSeq:NM_016891.3 Ppp2r1a

Other Identifiers

10442155

1415819_a_at

1438174_x_at

1438383_x_at

1438991_x_at

1455929_x_at

17333854

4363977

4498080

4511887

4513363

4580983

4673175

4680277

4681489

4710422

4711095

4741461

4752952

4851234

4865035

4969377

4993248

5087220

5097027

5135097

5139700

51792

5337523

5340056

5374214

5503657

5541129

5542032

5606670

5611596

92573_at

A_51_P365578

A_55_P2500443

A_66_P109169

GE42751

GO:0000159

GO:0000775

GO:0002376

GO:0003824

GO:0004722

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0007059

GO:0007143

GO:0016328

GO:0016787

GO:0019888

GO:0022414

GO:0030425

GO:0035331

GO:0042995

GO:0043005

GO:0043025

GO:0043029

GO:0043226

GO:0045202

GO:0046982

GO:0051232

GO:0051306

GO:0051754

GO:0051898

GO:0090443

GO:0098772

GO:0098978

GO:0140013

GO:0140096

GO:1903538

GO:1990405

GO:2001241

ILMN_2606243

Msa.33643.0_f_at

Msa.6384.0_s_at

Z31244_s_at

mMC022484

Participates

as a candidate of

PP2A-subunit A [nucleoplasm] (Mus musculus)

Other forms of this molecule

PP2A A subunit [cytosol]

Inferred From

PPP2R1A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_058587.1

ENSEMBL

ENSMUST00000007708, ENSMUSP00000007708, ENSMUSG00000007564

ZINC target

Q76MZ3

PRO

Q76MZ3

GlyGen

Q76MZ3

MGI

1926334

PDB

2PF4, 2IAE, 3FGA, 6EF4

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.743	4
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.669	3
UniProt:P35569 Irs1	8	p-Irs1 [cytosol] (R-MMU-2671869) phospho-Irs1 [plasma membrane] (R-MMU-2445090) Irs1 [plasma membrane] (R-MMU-2425392) Phospho-IRS1 (by NTRK1) [cytosol] (R-MMU-198285) Irs1 [cytosol] (R-MMU-198257) Irs1 [cytosol] (R-MMU-74769) phospho-Irs1 [cytosol] (R-MMU-74772) phospho-Irs1 [plasma membrane] (R-MMU-198366)	0.462	2

Cite Us!