Reactome | TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-MMU-166172

Type

Complex

Species

Mus musculus

Compartment

endosome membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 Ticam1 [cytosol] (Mus musculus)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

Participates

as an output of

Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)

as an input of

TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)

as a component of

TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

as a member of

TRIF:activated TLR4 [endosome membrane] (Mus musculus)

Inferred From

TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)

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