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What is Reactome ?
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Traf6 [cytosol]
Stable Identifier
R-MMU-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
TRAF6, P70196
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Auto-ubiquitination of TRAF6 (Mus musculus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Translocation of TRAF6 to CBM complex (Mus musculus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK1 induces oligomerisation of TRAF6 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 is K63 poly-ubiquitinated (Mus musculus)
Traf6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p62:MEKK3 binds to TRAF6 (Mus musculus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Alpha-protein kinase 1 signaling pathway (Mus musculus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MALT1 oligomers (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 oligomer autoubiquitinates (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Mus musculus)
TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 oligomerizes (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Mus musculus)
TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Auto-ubiquitination of TRAF6 (Mus musculus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Mus musculus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Mus musculus)
TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Oligomerization of TRAF6 (Mus musculus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Mus musculus)
CBM oligomer:TRAF6 [plasma membrane] (Mus musculus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Mus musculus)
MALT1oligomer:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Mus musculus)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Mus musculus)
TRAF6 oligomer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Mus musculus)
CBM oligomer:TRAF6 [plasma membrane] (Mus musculus)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Mus musculus)
MALT1oligomer:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
RIP2 is K63 polyubiquitinated (Mus musculus)
RIP2 ubiquitin ligases [cytosol] (Mus musculus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Pellino ubiquitinates hp-IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Pellino ubiquitinates hp-IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Pellino ubiquitinates hp-IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)
RIP1 ubiqutin ligases [cytosol] (Mus musculus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Mus musculus)
Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Pellino ubiquitinates hp-IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Pellino ubiquitinates hp-IRAK1 (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Ub-specific processing proteases (Mus musculus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRIF signals cell death from the nucleus (Mus musculus)
TRAF6 binds to p75NTR:NRIF (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 polyubiquitinates NRIF (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Regulated proteolysis of p75NTR (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IKK-beta is recruited (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
MYD88 dissociates (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
TRAF6 is auto-ubiquitinated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p62 is recruited and forms a complex with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
p62 recruits an atypical PKC (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
Traf6 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70196 Traf6
Gene Names
Traf6
Chain
chain:1-530
Reference Genes
BioGPS Gene:22034 Traf6
KEGG:mmu:22034 Traf6
Monarch:22034 Traf6
NCBI Gene:22034 Traf6
UCSC:P70196 Traf6
Reference Transcript
RefSeq:NM_001303273.1 Traf6
RefSeq:NM_009424.3 Traf6
Participates
as a component of
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Mus musculus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Mus musculus)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Mus musculus)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Mus musculus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
MEKK1:activated TRAF6 [cytosol] (Mus musculus)
MALT1oligomer:TRAF6 [cytosol] (Mus musculus)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Mus musculus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Mus musculus)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Mus musculus)
hp-IRAK1:3xTRAF6 [cytosol] (Mus musculus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
TRAF6 homotrimer [cytosol] (Mus musculus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
as an input of
IRAK2 induces TRAF6 oligomerization (Mus musculus)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)
Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)
Translocation of TRAF6 to CBM complex (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
TRAF6 binds MEKK1 (Mus musculus)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)
Oligomerization of TRAF6 (Mus musculus)
TRAF6 binds MALT1 oligomers (Mus musculus)
TRAF6 oligomerizes (Mus musculus)
p62:MEKK3 binds to TRAF6 (Mus musculus)
IRAK1 induces oligomerisation of TRAF6 (Mus musculus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
TRAF2, TRAF6 [cytosol] (Mus musculus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Mus musculus)
as a repeated unit of
TRAF6 oligomer [cytosol] (Mus musculus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [endosome membrane]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033450.2
,
NP_001290202.1
ENSEMBL
ENSMUSG00000027164
,
ENSMUST00000004949
,
ENSMUSP00000004949
PRO
P70196
MGI
108072
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62991 UBIQ
0.835
5
UniProt:Q9QZH6
2
Ecsit [mitochondrial inner membrane]
(R-MMU-5689047)
Ecsit [cytosol]
(R-MMU-168064)
0.729
5
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.623
4
UniProt:Q61084
1
MAP3K3 [cytosol]
(R-MMU-507725)
0.589
5
UniProt:Q8C0E5 Q8C0E5
0.581
3
UniProt:Q8K4B2
1
IRAK3 [cytosol]
(R-MMU-166103)
0.547
3
UniProt:Q8N7N6 CIKS
0.547
4
UniProt:Q62227
1
Nr0b2 [nucleoplasm]
(R-MMU-376312)
0.537
5
UniProt:P17879
4
HSPA1A [nucleoplasm]
(R-MMU-6792605)
HSPA1A [extracellular region]
(R-MMU-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-MMU-6801496)
HSPA1A [cytosol]
(R-MMU-6792602)
0.524
3
UniProt:Q9EQY0
2
phospho-p-S724-ERN1 [endoplasmic reticulum membrane]
(R-MMU-381029)
ERN1 [endoplasmic reticulum membrane]
(R-MMU-381076)
0.524
6
UniProt:Q793I8
2
Tifa [cytosol]
(R-MMU-451582)
phospho-Tifa [cytosol]
(R-MMU-9645512)
0.508
2
UniProt:O35305
1
TNFRSF11A [plasma membrane]
(R-MMU-5668756)
0.508
2
UniProt:P27512
1
Cd40 [plasma membrane]
(R-MMU-198117)
0.508
2
UniProt:Q96CG3 TIFA
2
TIFA [cytosol]
(R-HSA-451582)
p-T9-TIFA [cytosol]
(R-HSA-9645512)
0.499
4
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