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phospho-Akt2 [cytosol]
Stable Identifier
R-MMU-166800
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-T309,S474-AKT2, Q60823
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1/S Transition (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
AKT phosphorylates MDM2 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
AKT phosphorylates TSC2, inhibiting it (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
CD28 co-stimulation (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
AKT interacts and phosphorylates Cot (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
PDPK1 phosphorylates AKT at T308 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
CTLA4 inhibitory signaling (Mus musculus)
Dephosphorylation of AKT by PP2A (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
AKT phosphorylates targets in the cytosol (Mus musculus)
AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates IKKalpha (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates MDM2 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates MKRN1 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates TSC2, inhibiting it (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates caspase-9 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PHLPP dephosphorylates S473 in AKT (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
PDPK1 phosphorylates AKT at T308 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN stability and activity (Mus musculus)
AKT phosphorylates MKRN1 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
MTOR signalling (Mus musculus)
Inhibition of TSC complex formation by PKB (Mus musculus)
Phosphorylation of TSC2 by PKB (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Phosphorylation of complexed TSC2 by PKB (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
Downregulation of ERBB2:ERBB3 signaling (Mus musculus)
Phosphorylation of USP8 by P-AKT (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
PDPK1 phosphorylates AKT2 (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
Activation of AKT2 (Mus musculus)
PDPK1 phosphorylates AKT2 (Mus musculus)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
PDPK1 phosphorylates AKT at T308 (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Rab regulation of trafficking (Mus musculus)
RAB GEFs exchange GTP for GDP on RABs (Mus musculus)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)
p-T,p-S-AKT [cytosol] (Mus musculus)
phospho-Akt2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60823 Akt2
Gene Names
Akt2
Chain
chain:1-481
Reference Genes
BioGPS Gene:11652 Akt2
ENSEMBL:ENSMUSG00000004056 Akt2
KEGG Gene (Mus musculus):11652 Akt2
Monarch:11652 Akt2
NCBI Gene:11652 Akt2
UCSC:Q60823 Akt2
Reference Transcript
RefSeq:XM_006539481.3 Akt2
RefSeq:NM_001331108.1 Akt2
RefSeq:XM_006539477.1 Akt2
RefSeq:XM_006539480.1 Akt2
RefSeq:NM_001331109.1 Akt2
RefSeq:NM_007434.4 Akt2
RefSeq:NM_001110208.2 Akt2
Other Identifiers
10374364
10551393
105942_at
11652
1421324_a_at
1424480_s_at
1455703_at
160558_at
17475640
4365676
4374240
4442111
4444996
4472692
4487630
4602651
4643635
4735625
4744119
4750137
4791111
4850795
4926906
4932874
4966463
4980202
5005439
5044805
5052258
5141005
5149425
5212646
5288465
5422350
5563024
5579218
5599858
5606149
5614765
A_51_P408044
A_52_P2977
A_55_P2025228
A_55_P2066518
A_55_P2066523
A_66_P135179
GE34739
GE39473
GO:0000166
GO:0001934
GO:0003674
GO:0004672
GO:0004674
GO:0005080
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005783
GO:0005829
GO:0005886
GO:0005938
GO:0005975
GO:0005977
GO:0005978
GO:0006006
GO:0006091
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006605
GO:0006629
GO:0006810
GO:0006915
GO:0007009
GO:0007165
GO:0007275
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008286
GO:0008643
GO:0009056
GO:0009058
GO:0009967
GO:0010628
GO:0010748
GO:0010765
GO:0010907
GO:0010918
GO:0015031
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016529
GO:0016740
GO:0018105
GO:0019899
GO:0030154
GO:0030335
GO:0031340
GO:0031410
GO:0031982
GO:0032000
GO:0032287
GO:0032587
GO:0032593
GO:0032868
GO:0032869
GO:0032991
GO:0033119
GO:0033138
GO:0034641
GO:0035556
GO:0040011
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0043231
GO:0043491
GO:0044281
GO:0045429
GO:0045725
GO:0045944
GO:0046326
GO:0046872
GO:0048856
GO:0048870
GO:0050927
GO:0055085
GO:0061024
GO:0065002
GO:0071407
GO:0071486
GO:0072659
GO:0090314
GO:0090630
GO:0097473
GO:2000147
ILMN_1218595
ILMN_1251040
Msa.1786.0_s_at
mMC018059
mMR030538
w85443_s_at
Participant Of
hasComponent
p-T309,S474-AKT2:PIP3 [plasma membrane]
hasCandidate
p-T,p-S-AKT [cytosol]
Other forms of this molecule
p-T309, S474-Akt2 [plasma membrane]
phospho-Akt2 [cytosol]
phospho-Akt2 [nucleoplasm]
Akt2 [cytosol]
Akt2 [plasma membrane]
phospho-Akt2 [plasma membrane]
Inferred From
p-T309,S474-AKT2 [cytosol] (Homo sapiens)
p-T309,S474-AKT2 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 309
Coordinate
309
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 474
Coordinate
474
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001318038.1
,
NP_001103678.1
,
XP_006539544.1
,
XP_006539540.1
,
XP_006539543.1
,
NP_031460.1
,
NP_001318037.1
IntEnz
2.7.11.1
Ensembl
ENSMUST00000051356
,
ENSMUSP00000103981
,
ENSMUST00000108344
,
ENSMUSP00000103980
,
ENSMUST00000108343
,
ENSMUSG00000004056
,
ENSMUSP00000052103
,
ENSMUST00000167435
,
ENSMUSP00000132141
PRO
Q60823
MGI
104874
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.499
2
UniProt:P13639 EEF2
10
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
EEF2 [cytosol]
(R-HSA-156901)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.499
2
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.499
2
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