Reactome | Cyfip2 [cytosol]

Cyfip2 [cytosol]

Stable Identifier

R-MMU-1671642

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CYFIP2, Q5SQX6

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
      - ABL phosphorylates WAVEs (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
      - Detachment of WASP/WAVE (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
      - p-ERK phosphorylates WAVEs and ABI (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate WASPs and WAVEs (Mus musculus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        ABL phosphorylates WAVEs (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        Detachment of WASP/WAVE (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-ERK phosphorylates WAVEs and ABI (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
    - RHO GTPase cycle (Mus musculus)
      - RAC1 GTPase cycle (Mus musculus)
        
        RAC1 binds effectors at the plasma membrane (Mus musculus)
        
        RAC1 effectors [cytosol] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Mus musculus)
        
        RAC1 effectors [cytosol] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        CYFIP1,CYFIP2 [cytosol] (Mus musculus)
        
        Cyfip2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q5SQX6

Gene Names

Cyfip2

Reference Genes

BioGPS Gene:76884 Cyfip2

ENSEMBL:ENSMUSG00000020340

ENSEMBL:ENSMUSG00000020340.17 Cyfip2

KEGG Gene (Mus musculus):76884 Cyfip2

Monarch:76884 Cyfip2

NCBI Gene:76884 Cyfip2

UCSC:Q5SQX6 Cyfip2

Reference Transcript

Other Identifiers

102009_at

10385391

1428347_at

1449273_at

162711_at

17262065

4309060

4360177

4407179

4431661

4433458

4502183

4503428

4528612

4663602

4685867

4688308

4750537

4755028

4773844

4791220

4792372

4820316

4850004

4887061

4910659

4963242

5028984

5058382

5117051

5141122

5153144

5164385

5181129

5331329

5402508

5424728

5434682

5486794

5608914

76884

A_52_P359745

A_52_P536947

A_55_P1962771

GE38663

GE40196

GO:0000902

GO:0005515

GO:0005634

GO:0005737

GO:0006915

GO:0007010

GO:0007155

GO:0007411

GO:0012501

GO:0023052

GO:0030031

GO:0030154

GO:0030833

GO:0031175

GO:0031209

GO:0031267

GO:0043005

GO:0043226

GO:0045202

GO:0045862

GO:0048471

GO:0048856

GO:0051388

GO:0065003

GO:0097484

GO:0098609

ILMN_1232800

ILMN_2670713

mMC004258

mMR030068

Participates

as a member of

CYFIP1,CYFIP2 [cytosol] (Mus musculus)

Inferred From

CYFIP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001239389.1, NP_598530.2, NP_001239388.1

Ensembl

ENSMUSP00000090853, ENSMUSP00000090854, ENSMUST00000093166, ENSMUST00000093165, ENSMUST00000165599, ENSMUSG00000020340, ENSMUSP00000127586

PRO

Q5SQX6

MGI

1924134

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.527	3

Cite Us!