Reactome | Brk1 [cytosol]

Brk1 [cytosol]

Stable Identifier

R-MMU-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

BRK1, Q91VR8

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
      - ABL phosphorylates WAVEs (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
      - Detachment of WASP/WAVE (Mus musculus)
        
        Mother filament:branching complex [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        WAVE Regulatory Complex [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
      - p-ERK phosphorylates WAVEs and ABI (Mus musculus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Mus musculus)
        
        p-Y,S,T-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Mus musculus)
        
        p-Y-WRC [cytosol] (Mus musculus)
        
        Brk1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91VR8

Gene Names

Brk1

Reference Genes

BioGPS Gene:101314 Brk1

ENSEMBL:ENSMUSG00000033940

ENSEMBL:ENSMUSG00000033940.9 Brk1

KEGG Gene (Mus musculus):101314 Brk1

Monarch:101314 Brk1

NCBI Gene:101314 Brk1

UCSC:Q91VR8 Brk1

Reference Transcript

RefSeq:NM_133937.1 Brk1

Other Identifiers

101314

10540785

1423188_a_at

1423189_at

17461793

4386901

4590148

5066915

5075885

5478594

5600746

97311_at

A_51_P299155

A_66_P126492

GE102408

GE127671

GO:0001701

GO:0005737

GO:0005856

GO:0007010

GO:0007015

GO:0008064

GO:0010592

GO:0016601

GO:0023052

GO:0030027

GO:0030036

GO:0031209

GO:0031267

GO:0031334

GO:0042802

GO:0043226

GO:0044877

GO:0048144

GO:0048146

GO:0048856

GO:0048870

GO:0065003

GO:2000601

ILMN_2706857

ILMN_2958417

aa033154_s_at

mMC012146

Participates

as a candidate of

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_598698.1

Ensembl

ENSMUSP00000041644, ENSMUSG00000033940, ENSMUST00000035725

PRO

Q91VR8

MGI

1915406

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