Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-MMU-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P06240

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
        
        FYN,LCK [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
        
        FYN,LCK [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by SCF-KIT (Mus musculus)
    - Dimerization of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Disassociation and translocation of STATs to the nucleus (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Indirect recruitment of GAB2 to p-KIT (Mus musculus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - JAK2 binds to p-KIT (Mus musculus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation and activation of VAV1 (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation of GAB2 by SFKs (Mus musculus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation of JAK2 (Mus musculus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation of SHP2 by SFKs (Mus musculus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Recruitment of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Regulation of KIT signaling (Mus musculus)
      - Interaction of APS and p-KIT (Mus musculus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Phosphorylation of APS (Mus musculus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - Recruitment of CBL to KIT (Mus musculus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - SHP2 interacts with p-KIT (Mus musculus)
      - SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
    - Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
        
        SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase cycle (Mus musculus)
      - RHOH GTPase cycle (Mus musculus)
        
        RHOH binds effectors at the plasma membrane (Mus musculus)
        
        RHOH effectors [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Mus musculus)
        
        RHOH effectors [cytosol] (Mus musculus)
        
        LCK [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P06240 Lck

Gene Names

Lck, Lsk-t

Chain

initiator methionine:, chain:2-509

Reference Genes

BioGPS Gene:16818 Lck

KEGG:mmu:16818 Lck

Monarch:16818 Lck

NCBI Gene:16818 Lck

UCSC:P06240 Lck

Reference Transcript

Other Identifiers

102809_s_at

10516620

1425396_a_at

1439145_at

1439146_s_at

16818

17430413

4365171

4400266

4406208

4558922

4568065

4636803

4671941

4683421

4695333

4810598

4814668

4988917

5150457

5186492

5290956

5293679

5343788

5394055

5394720

5400253

5463215

5549197

5565059

A_51_P141288

A_55_P2506985

GE112706

GE1466813

GO:0000242

GO:0001772

GO:0001784

GO:0002376

GO:0003823

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0004722

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006882

GO:0006919

GO:0007166

GO:0007169

GO:0009410

GO:0009612

GO:0010038

GO:0010628

GO:0016004

GO:0016740

GO:0016787

GO:0019901

GO:0019903

GO:0030139

GO:0030154

GO:0030217

GO:0031410

GO:0034116

GO:0035556

GO:0038094

GO:0042110

GO:0042169

GO:0042492

GO:0042531

GO:0042542

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043226

GO:0043274

GO:0043548

GO:0044877

GO:0045087

GO:0045121

GO:0045588

GO:0045589

GO:0050852

GO:0050853

GO:0050856

GO:0050870

GO:0051117

GO:0051209

GO:0055085

GO:0070474

GO:0098542

GO:0098772

GO:0098978

GO:0099091

GO:0140096

GO:0160162

GO:1903039

GO:1990405

GO:2001244

ILMN_1224526

ILMN_2651137

mMC001127

x03533_s_at

Participates

as a member of

as an input of

Active FLT3 binds to LCK (Mus musculus)

as a component of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-Y394-LCK [plasma membrane]

Lck [cytosol]

phospho-p-Y505-LCK [plasma membrane]

phospho-p-Y394-LCK [cytosol]

Inferred From

LCK [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006502881.1, NP_001155905.1, NP_034823.1

ZINC - Investigational

LCK_MOUSE

ZINC - World Drugs

LCK_MOUSE

ENSEMBL

ENSMUSP00000099656, ENSMUSP00000066209, ENSMUST00000067240, ENSMUST00000102596

IntEnz

2.7.10.2

ZINC - FDA approved

LCK_MOUSE

ZINC - Substances

LCK_MOUSE

ZINC target

P06240

PRO

P06240

MGI

96756

ZINC - Predictions - Purchasable

LCK_MOUSE

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49710 HCLS1			0.704	6
UniProt:P06332	2	Cd4 [clathrin-coated endocytic vesicle membrane] (R-MMU-8869082) Cd4 [plasma membrane] (R-MMU-167542)	0.681	3
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
UniProt:P06800	2	PTPRC [secretory granule membrane] (R-MMU-6806150) PTPRC [plasma membrane] (R-MMU-197931)	0.59	2
UniProt:O92972 POLG			0.589	2
UniProt:P01731	1	Cd8a [plasma membrane] (R-MMU-197601)	0.573	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.558	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.524	2
UniProt:Q9QXK9	1	Sh2d2a [cytosol] (R-MMU-4420125)	0.508	3

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