Reactome | MAP2K3 [cytosol]

MAP2K3 [cytosol]

Stable Identifier

R-MMU-168051

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

O09110

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        activated TAK1 mediates p38 MAPK activation (Mus musculus)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
        
        MAP2K3,MAP2K6 [cytosol] (Mus musculus)
        
        MAP2K3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O09110

Reference Genes

BioGPS Gene:26397

ENSEMBL:ENSMUSG00000018932

ENSEMBL:ENSMUSG00000018932.10

KEGG Gene (Mus musculus):26397

Monarch:26397

NCBI Gene:26397

UCSC:O09110

Reference Transcript

RefSeq:NM_008928.4

Other Identifiers

10376733

1425456_a_at

1451714_a_at

17250533

26397

4493378

4547090

4584527

4709038

4755508

4794175

4842578

4925364

4927632

5014117

5110502

5145196

5243727

5276134

5365878

5520623

5536155

93314_g_at

93315_at

A_51_P272817

D87115_s_at

GE39232

GO:0000165

GO:0000166

GO:0001817

GO:0001934

GO:0002931

GO:0003012

GO:0003013

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0006351

GO:0006355

GO:0006468

GO:0006954

GO:0007507

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0023052

GO:0031098

GO:0035331

GO:0035924

GO:0036211

GO:0038066

GO:0043410

GO:0043536

GO:0045893

GO:0048856

GO:0048870

GO:0051770

GO:0060048

GO:0071222

GO:0072709

GO:0106310

GO:0140096

ILMN_2659644

mMC013662

Participates

as a member of

MAP2K3,MAP2K6 [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-S218,T222-MAP2K3 [cytosol]

phospho-p-S218,T222-MAP2K3 [nucleoplasm]

Inferred From

MAP2K3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032954.1

Ensembl

ENSMUSG00000018932, ENSMUST00000019076, ENSMUSP00000019076

PRO

O09110

MGI

1346868

PDB

1LEZ

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