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CHUK [cytosol]
Stable Identifier
R-MMU-168104
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q60680
Locations in the PathwayBrowser for interactor UniProt:P45481 Crebbp
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
AKT phosphorylates targets in the cytosol (Mus musculus)
AKT phosphorylates IKKalpha (Mus musculus)
CHUK [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60680
Reference Genes
ENSEMBL:ENSMUSG00000025199
UCSC:Q60680
Participates
as a component of
IKKA dimer [cytosol] (Mus musculus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
as an input of
AKT phosphorylates IKKalpha (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
Other forms of this molecule
phospho-p-Y187,Y198-CHUK [cytosol]
phospho-p-T23-CHUK [cytosol]
phospho-p-S176,S180-CHUK [cytosol]
Inferred From
CHUK [cytosol]
(Homo sapiens)
Cross References
PRO
Q60680
MGI
99484
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88522
5
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-MMU-4755449)
IKBKG [cytosol]
(R-MMU-168108)
Ub-285-IKBKG [cytosol]
(R-MMU-741397)
K63polyUb-IKBKG [cytosol]
(R-MMU-202530)
IKBKG [nucleoplasm]
(R-MMU-4755413)
0.85
6
UniProt:O88351
2
phospho-p-S177,S181-IKBKB [cytosol]
(R-MMU-202506)
IKBKB [cytosol]
(R-MMU-168114)
0.656
4
UniProt:C3VPR6
2
K63polyUb-NLRC5 [cytosol]
(R-MMU-9750938)
NLRC5 [cytosol]
(R-MMU-937324)
0.524
4
UniProt:P70434
3
phospho-Irf7 [nucleoplasm]
(R-MMU-450270)
phospho-Irf7 [cytosol]
(R-MMU-450318)
Irf7 [cytosol]
(R-MMU-450281)
0.524
3
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.508
2
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