Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IKBKB [cytosol]
Stable Identifier
R-MMU-168114
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
O88351
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Activation of IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
PKR-mediated signaling (Mus musculus)
IKK complex is activated by PKR (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
NEMO binds polyubiquitinated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
Phosphorylation of IKK-beta by TAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK1 recruits IKK complex (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Mus musculus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
LRRC14 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
USP18 binds IKBKG within IKK complex (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
IKBKB dimer [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IKK-beta is recruited (Mus musculus)
IKBKB dimer [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
IKBKB dimer [cytosol] (Mus musculus)
IKBKB [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O88351
Reference Genes
BioGPS Gene:16150
ENSEMBL:ENSMUSG00000031537
KEGG Gene (Mus musculus):16150
Monarch:16150
NCBI Gene:16150
Reference Transcript
RefSeq:NM_010546.2
Participates
as a component of
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
IKBKB dimer [cytosol] (Mus musculus)
CHUK:IKBKB:LRRC14 [cytosol] (Mus musculus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Mus musculus)
CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
as an input of
LRRC14 binds IKBKB and CHUK (Mus musculus)
NLRC5 binds IKBKB and CHUK (Mus musculus)
CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Mus musculus)
Other forms of this molecule
phospho-p-S177,S181-IKBKB [cytosol]
Inferred From
IKBKB [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_034676.1
ZINC - Substances
IKKB_MOUSE
ZINC target
O88351
PRO
O88351
ZINC - Predictions - Purchasable
IKKB_MOUSE
MGI
1338071
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88522
5
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-MMU-4755449)
IKBKG [cytosol]
(R-MMU-168108)
Ub-285-IKBKG [cytosol]
(R-MMU-741397)
K63polyUb-IKBKG [cytosol]
(R-MMU-202530)
IKBKG [nucleoplasm]
(R-MMU-4755413)
0.896
8
UniProt:Q60680
4
phospho-p-Y187,Y198-CHUK [cytosol]
(R-MMU-9861501)
phospho-p-T23-CHUK [cytosol]
(R-MMU-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-MMU-177667)
CHUK [cytosol]
(R-MMU-168104)
0.656
4
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.508
2
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text