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Ripk1 [cytosol]
Stable Identifier
R-MMU-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
RIPK1, Q60855
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRIF-mediated programmed cell death (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIP3 binds TRIF to mediate necroptosis (Mus musculus)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Mus musculus)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRIF:activated TLR4 [endosome membrane] (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TLR4-induced ripoptosome assembly (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Ub-specific processing proteases (Mus musculus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)
USP21:RIPK1,DDX58 [cytosol] (Mus musculus)
RIPK1, DDX58 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Dimerization of procaspase-8 (Mus musculus)
TNF-mediated dimerization of procaspase-8 (Mus musculus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
RIPK1 is phosphorylated (Mus musculus)
RIPK1:RIPK3 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Mus musculus)
RIPK1:RIPK3 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK3 is phosphorylated (Mus musculus)
RIPK1:RIPK3 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Mus musculus)
RIPK1:RIPK3 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signalling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1 is deubiquitinated (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Mus musculus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFR1-induced NFkappaB signaling pathway (Mus musculus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
Ripk1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60855
Gene Names
Ripk1
Reference Genes
BioGPS Gene:19766 Ripk1
ENSEMBL:ENSMUSG00000021408
ENSEMBL:ENSMUSG00000021408 Ripk1
KEGG Gene (Mus musculus):19766 Ripk1
Monarch:19766 Ripk1
NCBI Gene:19766 Ripk1
UCSC:Q60855 Ripk1
Reference Transcript
RefSeq:XM_006516609.3 Ripk1
RefSeq:NM_009068.3 Ripk1
RefSeq:XM_006516607.3 Ripk1
Other Identifiers
10404506
130183_at
1419508_at
1439273_at
1449485_at
17286472
19766
4387682
4499854
4576677
4587400
4619144
4679401
4705696
4738836
4769386
4792006
4886540
4937728
4942812
4968495
4977703
5073064
5165706
5165855
5170973
5475993
5598996
5609742
97091_at
AA186144_at
A_51_P430952
A_52_P174775
A_52_P452740
GE33576
GO:0003674
GO:0004672
GO:0005515
GO:0005524
GO:0006464
GO:0006468
GO:0007165
GO:0008150
GO:0016301
GO:0043167
ILMN_2753492
U25995_s_at
mMR026803
Participates
as a component of
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Mus musculus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Mus musculus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
RIPK1:RIPK3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Mus musculus)
TRAF2:TRADD:RIPK1 [cytosol] (Mus musculus)
as a member of
RIPK1, DDX58 [cytosol] (Mus musculus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Mus musculus)
as an input of
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
Other forms of this molecule
Ripk1 [cytosol]
Ripk1 [cytosol]
Ripk1 [cytosol]
Ripk1 [cytosol]
phospho-Ripk1 [cytosol]
Ripk1 [cytosol]
Inferred From
RIPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006516672.1
,
XP_006516670.1
,
NP_033094.3
Ensembl
ENSMUSP00000021844
,
ENSMUSG00000021408
,
ENSMUST00000021844
,
ENSMUSP00000129831
,
ENSMUST00000167374
PRO
Q60855
MGI
108212
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.886
8
UniProt:P25118
1
Tnfrsf1a [plasma membrane]
(R-MMU-66344)
0.669
3
UniProt:P62991 UBIQ
0.667
5
UniProt:Q9QZL0
7
Ripk3 [cytosol]
(R-MMU-9686937)
Ripk3 [cytosol]
(R-MMU-9687819)
Ripk3 [cytosol]
(R-MMU-9686917)
phospho-Ripk3 [cytosol]
(R-MMU-9686933)
Ripk3 [cytosol]
(R-MMU-9688825)
phospho-Ripk3 [cytosol]
(R-MMU-5218873)
Ripk3 [cytosol]
(R-MMU-450328)
0.589
4
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
3
UniProt:Q3U0V2
1
Tradd [cytosol]
(R-MMU-66376)
0.499
2
UniProt:P33896 Ifnar1
3
Ifnar1 [plasma membrane]
(R-MMU-877334)
Ifnar1 [plasma membrane]
(R-MMU-912671)
phospho-Ifnar1 [plasma membrane]
(R-MMU-909675)
0.463
2
UniProt:P47741
1
Tnfrsf4 [plasma membrane]
(R-MMU-5692210)
0.462
7
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