Reactome | RIPK1 [cytosol]

RIPK1 [cytosol]

Stable Identifier

R-MMU-168651

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q60855

Locations in the PathwayBrowser for interactor UniProt:P33896 Ifnar1

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        IKK complex recruitment mediated by RIP1 (Mus musculus)
        
        TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)
        
        RIPK1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60855

Reference Genes

BioGPS Gene:19766

ENSEMBL:ENSMUSG00000021408

ENSEMBL:ENSMUSG00000021408.16

KEGG Gene (Mus musculus):19766

Monarch:19766

NCBI Gene:19766

UCSC:Q60855

Reference Transcript

Other Identifiers

10404506

130183_at

1419508_at

1439273_at

1449485_at

17286472

19766

4387682

4499854

4576677

4587400

4619144

4679401

4705696

4738836

4769386

4792006

4886540

4937728

4942812

4968495

4977703

5073064

5165706

5165855

5170973

5475993

5598996

5609742

97091_at

AA186144_at

A_51_P430952

A_52_P174775

A_52_P452740

A_55_P2506630

GE33576

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004706

GO:0005123

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006950

GO:0006954

GO:0006979

GO:0007165

GO:0008152

GO:0008625

GO:0010033

GO:0010628

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0031047

GO:0031264

GO:0031349

GO:0031625

GO:0032103

GO:0032757

GO:0032760

GO:0032991

GO:0033209

GO:0034612

GO:0035556

GO:0035591

GO:0036211

GO:0036289

GO:0042327

GO:0042802

GO:0042803

GO:0043065

GO:0043066

GO:0043068

GO:0043123

GO:0043124

GO:0043226

GO:0043235

GO:0043410

GO:0043525

GO:0044877

GO:0045651

GO:0045944

GO:0046330

GO:0046777

GO:0048856

GO:0050729

GO:0051092

GO:0060090

GO:0060545

GO:0060546

GO:0062100

GO:0065003

GO:0070105

GO:0070231

GO:0070266

GO:0070301

GO:0070513

GO:0070887

GO:0071356

GO:0071363

GO:0097191

GO:0097300

GO:0097342

GO:0097343

GO:0097527

GO:0106310

GO:0140096

GO:1900119

GO:1901026

GO:1901224

GO:1903265

GO:1903800

GO:1990000

GO:2000377

GO:2001237

GO:2001238

GO:2001240

ILMN_2753492

U25995_s_at

mMR026803

Participates

as a component of

as a member of

as an input of

Other forms of this molecule

K48polyUb-RIPK1 [cytosol]

PolyUb-RIPK1 [cytosol]

K63polyUb-RIPK1 [cytosol]

phospho-p-S166-RIPK1 [cytosol]

phospho-p-S357-RIPK1 [cytosol]

phospho-p-S320-RIPK1 [cytosol]

phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]

polyUb-K377,K604,K634-RIPK1 [cytosol]

RIPK1(325-671) [cytosol]

RIPK1(1-324) [cytosol]

K63,M1polyUb-RIPK1 [cytosol]

phospho-K63,Met1polyUb-p-S25-RIPK1 [cytosol]

K48polyUb-K571,K604,K627-RIPK1 [cytosol]

Inferred From

RIPK1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006516670.1, XP_006516672.1, NP_033094.3

Ensembl

ENSMUSP00000129831, ENSMUSG00000021408, ENSMUST00000167374, ENSMUST00000021844, ENSMUSP00000021844

PRO

Q60855

MGI

108212

PDB

8IB0

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61160	1	Fadd [cytosol] (R-MMU-54639)	0.886	9
UniProt:P25118	1	TNFRSF1A(30-45) [plasma membrane] (R-MMU-5675738)	0.758	4
UniProt:P62991 UBIQ			0.609	2
UniProt:Q9QZL0	8	phospho-p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-MMU-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-MMU-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-MMU-9687819) RIPK3(329-518) [cytosol] (R-MMU-9686937) RIPK3(1-328) [cytosol] (R-MMU-9686917) Ub-K55,363-RIPK3 [cytosol] (R-MMU-9688825) phospho-p-S199,227-RIPK3 [cytosol] (R-MMU-5218873) RIPK3 [cytosol] (R-MMU-450328)	0.589	4
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.576	4
UniProt:Q3U0V2	1	TRADD [cytosol] (R-MMU-66376)	0.499	2
UniProt:P33896 Ifnar1	3	Ifnar1 [plasma membrane] (R-MMU-912671) Ifnar1 [plasma membrane] (R-MMU-877334) phospho-Ifnar1 [plasma membrane] (R-MMU-909675)	0.463	2
UniProt:P47741	1	Tnfrsf4 [plasma membrane] (R-MMU-5692210)	0.462	7

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