Reactome | Syt1 [plasma membrane]

Syt1 [plasma membrane]

Stable Identifier

R-MMU-168786

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

SYT1, P46096

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - STON2 binds SYT proteins (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - SNX9 recruits components of the actin polymerizing machinery (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT1 dimer [plasma membrane] (Mus musculus)
        
        Syt1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P46096

Gene Names

Syt1

Reference Genes

BioGPS Gene:20979 Syt1

ENSEMBL:ENSMUSG00000035864

ENSEMBL:ENSMUSG00000035864 Syt1

KEGG Gene (Mus musculus):20979 Syt1

Monarch:20979 Syt1

NCBI Gene:20979 Syt1

UCSC:P46096 Syt1

Reference Transcript

Other Identifiers

10372324

105700_at

113587_at

1421990_at

1431191_a_at

1433884_at

17244843

20979

4360464

4367479

4371588

4400297

4483145

4587873

4616588

4621709

4652785

4694016

4711934

4899617

4962303

5003568

5064802

5120789

5189577

5265981

5331361

5349702

5480387

5532218

5532634

5545681

5584700

5603994

93005_at

A_51_P297900

A_51_P298873

A_52_P103929

A_52_P679799

A_52_P94201

A_55_P2058957

D37792_s_at

GE33752

GO:0003674

GO:0005544

GO:0005575

GO:0005622

GO:0005737

GO:0006810

GO:0007267

GO:0007269

GO:0008021

GO:0008150

GO:0008289

GO:0016020

GO:0031410

GO:0043167

GO:0043226

ILMN_1224963

ILMN_1226085

ILMN_2608410

ILMN_2608416

mMC018419

mMR026348

Participates

as a component of

SYT1 dimer [plasma membrane] (Mus musculus)

as an output of

Other forms of this molecule

Syt1 [clathrin-coated endocytic vesicle membrane]

Syt1 [clathrin-sculpted acetylcholine transport vesicle membrane]

Syt1 [clathrin-sculpted glutamate transport vesicle membrane]

Syt1 [clathrin-sculpted monoamine transport vesicle membrane]

Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Inferred From

SYT1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001239270.1, XP_006513509.1, NP_033332.1, NP_001239271.1, XP_006513511.1, XP_017169355.1, XP_006513510.1

Ensembl

ENSMUST00000064054, ENSMUSP00000063293, ENSMUST00000105276, ENSMUSG00000035864, ENSMUSP00000100912

PRO

P46096

MGI

99667

PDB

5VFF, 5T0S, 5T0R, 5VFE, 5VFG

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49769 Psen1	7	Psen1 [azurophil granule membrane] (R-MMU-6799234) Psen1 N-term fragment [plasma membrane] (R-MMU-2534198) Psen1 [azurophil granule membrane] (R-MMU-6799235) Psen1 [plasma membrane] (R-MMU-201606) Psen1 [azurophil granule membrane] (R-MMU-6799209) Psen1(1-298) [plasma membrane] (R-MMU-206283) Psen1(299-467) [plasma membrane] (R-MMU-2534227)	0.571	6
UniProt:Q62108 Dlg4	3	Dlg4 [endocytic vesicle membrane] (R-MMU-416847) SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [cytosol] (R-MMU-6794267)	0.527	3
UniProt:Q8TAC9 SCAM5			0.524	2

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