Reactome | Syt2 [plasma membrane]

Syt2 [plasma membrane]

Stable Identifier

R-MMU-168795

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

SYT2, P46097

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - STON2 binds SYT proteins (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - SNX9 recruits components of the actin polymerizing machinery (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        STON2,1:SYT dimers [plasma membrane] (Mus musculus)
        
        SYT dimers [plasma membrane] (Mus musculus)
        
        SYT2 dimer [plasma membrane] (Mus musculus)
        
        Syt2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P46097

Gene Names

Syt2

Reference Genes

BioGPS Gene:20980 Syt2

ENSEMBL:ENSMUSG00000026452

KEGG Gene (Mus musculus):20980 Syt2

Monarch:20980 Syt2

NCBI Gene:20980 Syt2

UCSC:P46097 Syt2

Reference Transcript

Participates

as a component of

SYT2 dimer [plasma membrane] (Mus musculus)

Other forms of this molecule

Syt2 [clathrin-coated endocytic vesicle membrane]

Inferred From

SYT2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006529386.1, XP_006529385.1, NP_033333.2

PRO

P46097

MGI

99666

PDB

2NP0, 4KBB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10844 botB	8	botB LC [cytosol] (R-CBO-181489) botB HC [synaptic vesicle membrane] (R-CBO-5228953) botB LC disulfide bonded [extracellular region] (R-CBO-181565) botB HC disulfide bonded [extracellular region] (R-CBO-181507) botB LC disulfide bonded [synaptic vesicle membrane] (R-CBO-181465) botB HC disulfide bonded [synaptic vesicle membrane] (R-CBO-181459) botB HC disulfide bonded [plasma membrane] (R-CBO-181485) botB LC disulfide bonded [plasma membrane] (R-CBO-181466)	0.683	3

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