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phospho-Cdk1 [nucleoplasm]
Stable Identifier
R-MMU-170066
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
p-T161-CDK1, P11440
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Prophase (Mus musculus)
CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Condensation of Prophase Chromosomes (Mus musculus)
CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Nuclear Envelope Breakdown (Mus musculus)
Depolymerisation of the Nuclear Lamina (Mus musculus)
CDK1 phosphorylates LPIN (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)
p-CDK1/2:CCNA/p-T161-CDK1:CCNB1 [nucleoplasm] (Mus musculus)
CCNA:p-CDK1/2 [nucleoplasm] (Mus musculus)
CCNA:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)
CCNA:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)
p-4S-CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)
nuclear Cyclin B1:Cdc2 complexes [nucleoplasm] (Mus musculus)
p-4S-CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
Phosphorylation of the APC/C (Mus musculus)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Phosphorylation of Emi1 (Mus musculus)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)
CCNA:p-CDK1/2 [nucleoplasm] (Mus musculus)
CCNA:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
CDK1 phosphorylates RUNX2 (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
CDK1 phosphorylates MAPK6 (Mus musculus)
phospho-Cdk1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P11440 Cdk1
Gene Names
Cdk1, Cdc2, Cdc2a, Cdkn1
Chain
chain:1-297
Reference Genes
BioGPS Gene:12534 Cdk1
ENSEMBL:ENSMUSG00000019942 Cdk1
KEGG Gene (Mus musculus):12534 Cdk1
Monarch:12534 Cdk1
NCBI Gene:12534 Cdk1
UCSC:P11440 Cdk1
Reference Transcript
RefSeq:NM_007659.3 Cdk1
Other Identifiers
100128_at
10369815
12534
1448314_at
17241692
4472993
4588721
4720947
4881487
4934166
5093482
5121588
5251273
5275259
5480188
5511184
5551219
5556695
A_52_P339954
A_55_P2016647
A_55_P2016652
A_55_P2048588
GE1469937
GE33489
GO:0003674
GO:0004672
GO:0005524
GO:0006464
GO:0006468
GO:0008150
GO:0016301
GO:0043167
ILMN_2657844
ILMN_2698252
ILMN_2961747
Msa.18569.0_s_at
mMC016053
u58633_s_at
Participates
as a component of
CCNA:p-T161-CDK1 [nucleoplasm] (Mus musculus)
CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
p-4S-CCNB1:p-T161-CDK1 [nucleoplasm] (Mus musculus)
Other forms of this molecule
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [nucleoplasm]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [cytosol]
phospho-Cdk1 [cytosol]
Cdk1 [cytosol]
Cdk1 [nucleoplasm]
Cdk1 [endoplasmic reticulum membrane]
Inferred From
p-T161-CDK1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 161 (in Homo sapiens)
Coordinate
161
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_031685.2
IntEnz
2.7.11.23
ZINC - Substances
CDK1_MOUSE
ZINC - Biogenic
CDK1_MOUSE
ZINC target
P11440
Ensembl
ENSMUST00000119827
,
ENSMUST00000020099
,
ENSMUSP00000113184
,
ENSMUSG00000019942
,
ENSMUSP00000020099
PRO
P11440
ZINC - Predictions - Purchasable
CDK1_MOUSE
MGI
88351
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.623
4
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.623
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.623
3
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
0.623
4
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.623
4
UniProt:P33552 CKS2
0.623
4
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.623
4
UniProt:P20263
1
Pou5f1 [nucleoplasm]
(R-MMU-452472)
0.61
4
UniProt:Q61457
2
Ccne1 [nucleoplasm]
(R-MMU-68363)
Ccne1 [cytosol]
(R-MMU-157443)
0.589
3
UniProt:Q99640 PKMYT1
3
PKMYT1 [nucleoplasm]
(R-HSA-74386)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [cytosol]
(R-HSA-157457)
0.564
3
UniProt:Q9UJX3 ANAPC7
2
ANAPC7 [cytosol]
(R-HSA-174242)
ANAPC7 [nucleoplasm]
(R-HSA-174204)
0.499
2
UniProt:Q8IVT2 MISP
0.499
2
UniProt:P22674 CCNO
0.499
2
UniProt:Q14674 ESPL1
4
ESPL1(1507-1535) [cytosol]
(R-HSA-2500272)
ESPL1(1-1506) [cytosol]
(R-HSA-2467768)
ESPL1(1536-2120) [cytosol]
(R-HSA-2467767)
ESPL1 [cytosol]
(R-HSA-1638167)
0.499
2
UniProt:O43175 PHGDH
1
PHGDH [cytosol]
(R-HSA-977340)
0.499
2
UniProt:Q14204 DYNC1H1
3
DYNC1H1 [azurophil granule lumen]
(R-HSA-6799155)
DYNC1H1 [extracellular region]
(R-HSA-6806223)
DYNC1H1 [cytosol]
(R-HSA-380285)
0.499
2
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.499
2
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