Reactome | phospho-Cdk1 [nucleoplasm]

phospho-Cdk1 [nucleoplasm]

Stable Identifier

R-MMU-170066

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

p-T161-CDK1, P11440

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11440 Cdk1

Gene Names

Cdk1, Cdc2, Cdc2a, Cdkn1

Chain

chain:1-297

Reference Genes

BioGPS Gene:12534 Cdk1

ENSEMBL:ENSMUSG00000019942 Cdk1

KEGG Gene (Mus musculus):12534 Cdk1

Monarch:12534 Cdk1

NCBI Gene:12534 Cdk1

UCSC:P11440 Cdk1

Reference Transcript

RefSeq:NM_007659.3 Cdk1

Other Identifiers

100128_at

10369815

12534

1448314_at

17241692

4472993

4588721

4720947

4881487

4934166

5093482

5121588

5251273

5275259

5480188

5511184

5551219

5556695

A_52_P339954

A_55_P2016647

A_55_P2016652

A_55_P2048588

GE1469937

GE33489

GO:0000086

GO:0000166

GO:0000278

GO:0000307

GO:0003674

GO:0003682

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006091

GO:0006464

GO:0006468

GO:0006810

GO:0006913

GO:0006915

GO:0006950

GO:0007049

GO:0007095

GO:0007568

GO:0007569

GO:0008150

GO:0008219

GO:0008283

GO:0008353

GO:0009058

GO:0009636

GO:0010243

GO:0010628

GO:0010971

GO:0014070

GO:0014075

GO:0014823

GO:0015031

GO:0016301

GO:0016310

GO:0016572

GO:0016740

GO:0018105

GO:0018107

GO:0022607

GO:0030154

GO:0030261

GO:0030332

GO:0030496

GO:0030544

GO:0030855

GO:0031100

GO:0032991

GO:0034501

GO:0035173

GO:0040007

GO:0042307

GO:0042493

GO:0042542

GO:0042752

GO:0043066

GO:0043167

GO:0043226

GO:0044772

GO:0045471

GO:0045740

GO:0045931

GO:0046686

GO:0046688

GO:0048511

GO:0048678

GO:0048856

GO:0051276

GO:0051301

GO:0055015

GO:0060045

GO:0065003

GO:0070301

GO:0072686

GO:0090166

GO:0097125

GO:0097472

GO:1900182

GO:1905448

ILMN_2657844

ILMN_2698252

ILMN_2961747

Msa.18569.0_s_at

mMC016053

u58633_s_at

Participant Of

hasComponent

Other forms of this molecule

phospho-Cdk1 [nucleoplasm]

phospho-Cdk1 [cytosol]

Cdk1 [cytosol]

Cdk1 [nucleoplasm]

Cdk1 [endoplasmic reticulum membrane]

Inferred From

p-T161-CDK1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 161 (in Homo sapiens)

Coordinate

161

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_031685.2

IntEnz

2.7.11.23

ZINC - Substances

CDK1_MOUSE

ZINC - Biogenic

CDK1_MOUSE

Ensembl

ENSMUST00000020099, ENSMUSP00000020099, ENSMUSP00000113184, ENSMUSG00000019942, ENSMUST00000119827

ZINC target

P11440

PRO

P11440

ZINC - Predictions - Purchasable

CDK1_MOUSE

MGI

88351

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.623	4
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.623	3
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.623	4
UniProt:P14635 CCNB1	4	CCNB1 [cytosol] (R-HSA-157451) CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049)	0.623	4
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.623	4
UniProt:P33552 CKS2			0.623	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.623	4
UniProt:P20263	1	Pou5f1 [nucleoplasm] (R-MMU-452472)	0.61	4
UniProt:Q61457	2	Ccne1 [nucleoplasm] (R-MMU-68363) Ccne1 [cytosol] (R-MMU-157443)	0.589	3
UniProt:Q99640 PKMYT1	3	PKMYT1 [nucleoplasm] (R-HSA-74386) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [cytosol] (R-HSA-157457)	0.564	3
UniProt:Q9UJX3 ANAPC7	2	ANAPC7 [cytosol] (R-HSA-174242) ANAPC7 [nucleoplasm] (R-HSA-174204)	0.499	2
UniProt:Q8IVT2 MISP			0.499	2
UniProt:P22674 CCNO			0.499	2
UniProt:O43175 PHGDH	1	PHGDH [cytosol] (R-HSA-977340)	0.499	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [cytosol] (R-HSA-380285)	0.499	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.499	2
UniProt:Q14674 ESPL1	4	ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.499	2