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phospho-p-4S,T185,T186-TGFBR1 [plasma membrane]
Stable Identifier
R-MMU-170849
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
Q64729
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
Degradation of TGF-beta receptor complex (Mus musculus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGFBR2 phosphorylates TGFBR1 (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Mus musculus)
Disassembly of tight junctions (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
SMURF1 binds phosphorylated PARD6A (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
SMURF1 ubiquitinates RHOA (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Mus musculus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Mus musculus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Mus musculus)
p-TGFBR1 [plasma membrane] (Mus musculus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q64729
Reference Genes
BioGPS Gene:21812
ENSEMBL:ENSMUSG00000007613
KEGG:mmu:21812
Monarch:21812
NCBI Gene:21812
UCSC:Q64729
Reference Transcript
RefSeq:NM_001312869.1
RefSeq:NM_001312868.1
RefSeq:NM_009370.3
Other Identifiers
10504817
106644_at
1420893_a_at
1420894_at
1420895_at
17413915
21812
4355548
4431045
4455593
4480905
4519309
4710787
4890052
4905530
4908316
5034160
5227658
5367563
5458612
5476760
5579347
5603436
92427_at
A_51_P280137
A_52_P4538
A_55_P1960901
A_55_P1960906
A_55_P2137206
A_55_P2137211
GE33803
GO:0001501
GO:0001525
GO:0001701
GO:0001822
GO:0001824
GO:0001837
GO:0001935
GO:0001937
GO:0001938
GO:0002088
GO:0003222
GO:0003223
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005025
GO:0005102
GO:0005114
GO:0005515
GO:0005524
GO:0005634
GO:0005768
GO:0005886
GO:0005901
GO:0005923
GO:0006355
GO:0006468
GO:0006915
GO:0007165
GO:0007178
GO:0007179
GO:0007399
GO:0007507
GO:0008284
GO:0008354
GO:0008584
GO:0009791
GO:0009952
GO:0009986
GO:0010468
GO:0010628
GO:0010717
GO:0010718
GO:0012501
GO:0016020
GO:0016323
GO:0016324
GO:0016361
GO:0016740
GO:0019838
GO:0022414
GO:0030154
GO:0030198
GO:0030199
GO:0030307
GO:0030335
GO:0030336
GO:0031396
GO:0031410
GO:0031625
GO:0032331
GO:0032924
GO:0032991
GO:0035556
GO:0036446
GO:0042118
GO:0043065
GO:0043066
GO:0043226
GO:0043235
GO:0043542
GO:0043627
GO:0044877
GO:0045121
GO:0045602
GO:0045893
GO:0046332
GO:0046847
GO:0046872
GO:0048179
GO:0048185
GO:0048538
GO:0048663
GO:0048701
GO:0048705
GO:0048762
GO:0048844
GO:0048856
GO:0048870
GO:0050431
GO:0051491
GO:0051496
GO:0051897
GO:0060017
GO:0060021
GO:0060037
GO:0060043
GO:0060089
GO:0060317
GO:0060391
GO:0060395
GO:0060412
GO:0060978
GO:0060982
GO:0070021
GO:0070411
GO:0070723
GO:0071363
GO:0071560
GO:0140096
GO:1901203
GO:1902462
GO:1902894
GO:1902895
GO:1904018
GO:1905007
GO:1905075
GO:1905223
GO:2001235
GO:2001237
ILMN_1214505
ILMN_2602711
ILMN_2708965
ILMN_2708966
ILMN_2980532
d25540_s_at
mMC015662
mMC019469
mMR031099
Participates
as a component of
p-TGFBR1 [plasma membrane] (Mus musculus)
Other forms of this molecule
Ub-TGFBR1 [plasma membrane]
TGFBR1 [plasma membrane]
Inferred From
p-4S,T185,T186-TGFBR1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 165 (in Homo sapiens)
Coordinate
165
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 186 (in Homo sapiens)
Coordinate
186
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 189 (in Homo sapiens)
Coordinate
189
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 191 (in Homo sapiens)
Coordinate
191
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001299798.1
,
NP_001299797.1
,
NP_033396.1
ENSEMBL
ENSMUSP00000007757
,
ENSMUST00000044234
,
ENSMUSP00000048501
,
ENSMUST00000007757
ZINC - Substances
TGFR1_MOUSE
ZINC target
Q64729
PRO
Q64729
GlyGen
Q64729
MGI
98728
ZINC - Predictions - Purchasable
TGFR1_MOUSE
HMDB Protein
HMDBP14494
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q62312
2
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-MMU-4332222)
TGFBR2 [plasma membrane]
(R-MMU-170842)
0.667
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.576
6
UniProt:P49817 Cav1
6
caveolin-1 [lipid droplet]
(R-MMU-163603)
Cav1 [early endosome membrane]
(R-MMU-5368451)
Cav1 [endocytic vesicle membrane]
(R-MMU-535009)
Cav1 [lipid droplet]
(R-MMU-163510)
Cav1 [plasma membrane]
(R-MMU-534994)
Cav1 [Golgi membrane]
(R-MMU-204504)
0.558
4
UniProt:P15379
2
CD44 [plasma membrane]
(R-MMU-1031688)
CD44 [secretory granule membrane]
(R-MMU-6804776)
0.518
4
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