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Smad4 [cytosol]
Stable Identifier
R-MMU-170862
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
SMAD4, P97471
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Signaling by NODAL (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
WWTR1:p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by Activin (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Signaling by BMP (Mus musculus)
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
WWTR1:p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Smad4 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P97471 Smad4
Gene Names
Smad4, Dpc4, Madh4
Chain
chain:1-551
Reference Genes
BioGPS Gene:17128 Smad4
ENSEMBL:ENSMUSG00000024515 Smad4
KEGG Gene (Mus musculus):17128 Smad4
Monarch:17128 Smad4
NCBI Gene:17128 Smad4
UCSC:P97471 Smad4
Reference Transcript
RefSeq:NM_008540.2 Smad4
Other Identifiers
10459705
1422485_at
1422486_a_at
1422487_at
160440_at
17128
17355366
4353907
4395889
4627720
4755664
4814473
4889622
4893342
4963865
4967060
4969979
4993511
5062215
5075953
5080370
5174729
5219125
5221946
5224601
5340457
5443671
5456001
5583757
A_52_P611867
A_55_P2112617
A_55_P2112622
GE33977
GO:0003674
GO:0005515
GO:0005575
GO:0005667
GO:0006355
GO:0007165
GO:0007179
GO:0008150
GO:0009058
GO:0032991
GO:0034641
ILMN_2425011
ILMN_2706631
U79748_s_at
aa542171_at
mMC007586
mMR031218
Participates
as an input of
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
as a component of
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [cytosol] (Mus musculus)
Ub-SMAD4 [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
as an output of
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
Other forms of this molecule
Smad4 [nucleoplasm]
phospho-Smad4 [nucleoplasm]
Smad4 [nucleoplasm]
Inferred From
SMAD4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_032566.2
Ensembl
ENSMUST00000114939
,
ENSMUST00000025393
,
ENSMUSP00000025393
,
ENSMUSG00000024515
,
ENSMUSP00000110589
PRO
P97471
MGI
894293
PDB
3QSV
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8BUN5 Smad3
7
Smad3 [nucleoplasm]
(R-MMU-206150)
Smad3 [cytosol]
(R-MMU-6782830)
phospho-Smad3 [nucleoplasm]
(R-MMU-2187326)
phospho-Smad3 [nucleoplasm]
(R-MMU-2176471)
Smad3 [cytosol]
(R-MMU-170855)
p-S423,425-Smad3 [cytosol]
(R-MMU-9605416)
p-S423,425-Smad3 [nucleoplasm]
(R-MMU-1225907)
0.731
6
UniProt:Q60698
1
Ski [nucleoplasm]
(R-MMU-173473)
0.524
3
UniProt:Q8R1H0 HOP
0.499
2
UniProt:O95411 TIAF1
0.454
2
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