Reactome | Apob [plasma membrane]

Apob [plasma membrane]

Stable Identifier

R-MMU-171089

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

APOB(28-4563), E9Q414

Locations in the PathwayBrowser

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Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - LDLR is bound by DAB2 and ARH (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Dissociation of clathrin-associated proteins (Mus musculus)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - SNX9 recruits components of the actin polymerizing machinery (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Mus musculus)
        
        LDL:LDLR complex [plasma membrane] (Mus musculus)
        
        LDL [plasma membrane] (Mus musculus)
        
        Apob [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:E9Q414 Apob

Gene Names

Apob

Chain

signal peptide:1-27, chain:28-4505, chain:28-2178

Reference Genes

BioGPS Gene:238055 Apob

ENSEMBL:ENSMUSG00000020609 Apob

KEGG Gene (Mus musculus):238055 Apob

Monarch:238055 Apob

NCBI Gene:238055 Apob

UCSC:E9Q414 Apob

Reference Transcript

RefSeq:NM_009693.2 Apob

Other Identifiers

10394394

1455593_at

1457554_at

17273864

238055

4306053

4384633

4482838

4483189

4487797

4517859

4536182

4559041

4573383

4599026

4608353

4624176

4652178

4673553

4682581

4683372

4709837

4746661

4751261

4778016

4782327

4789210

4848268

4928570

4989594

5104947

5111596

5154650

5176104

5199967

5292540

5394337

5424126

5445027

5459183

5494124

5515030

5569270

5603115

96792_at

A_51_P380650

A_51_P413088

A_51_P436690

A_51_P470542

A_52_P441070

A_55_P1957198

GE1400721

GO:0003674

GO:0005319

GO:0006810

GO:0006869

GO:0008150

ILMN_2710942

Msa.19808.0_s_at

Msa.20048.0_s_at

mMC010539

Participates

as a component of

LDL [plasma membrane] (Mus musculus)

Other forms of this molecule

Apob [lysosomal lumen]

Apob(28-4505) [extracellular region]

Apob [clathrin-coated endocytic vesicle membrane]

Apob [endosome lumen]

Apob [endosome membrane]

Apob [clathrin-coated endocytic vesicle membrane]

Apob [plasma membrane]

Apob [endoplasmic reticulum lumen]

Apob [endoplasmic reticulum membrane]

Apob [smooth endoplasmic reticulum]

Apob [cytosol]

Apob [extracellular region]

Apob [early endosome]

AcK-Apob [extracellular region]

Apob [endocytic vesicle lumen]

Apob [extracellular region]

phospho-Apob [endoplasmic reticulum lumen]

Apob [endoplasmic reticulum lumen]

dHF-glutamyl semialdehyde (Pro)-OxoH-N'-formyl-L-kynurenine-Apob [extracellular region]

Apob [extracellular region]

Inferred From

APOB(28-4563) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_033823.2

Ensembl

ENSMUST00000037811, ENSMUSG00000020609, ENSMUSP00000036044

PRO

E9Q414

MGI

88052

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