Reactome | Cdc16 [nucleoplasm]

Cdc16 [nucleoplasm]

Stable Identifier

R-MMU-174049

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CDC16, Q8R349

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        Phosphorylation of the APC/C (Mus musculus)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Free APC/C phosphorylated by Plk1 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc16 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8R349

Gene Names

Cdc16

Reference Genes

BioGPS Gene:69957 Cdc16

ENSEMBL:ENSMUSG00000038416

KEGG:mmu:69957 Cdc16

Monarch:69957 Cdc16

NCBI Gene:69957 Cdc16

UCSC:Q8R349 Cdc16

Reference Transcript

RefSeq:NM_027276.2 Cdc16

Other Identifiers

10570397

1425554_a_at

17499353

4338252

4341222

4351846

4355872

4375732

4390957

4400686

4505513

4561422

4585370

4680978

4697185

4740191

4849177

4860836

4937140

4987762

4998561

5064595

5112791

5159279

5199778

5256930

5283698

5409008

5472381

5517258

5556278

5568097

69957

96236_at

A_51_P508349

A_52_P275152

A_55_P2617069

GE39735

GO:0005515

GO:0005634

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0016567

GO:0030163

GO:0031145

GO:0043226

GO:0045842

GO:0051301

GO:0070936

GO:0070979

GO:0072686

GO:0141198

ILMN_2709525

aa536849_s_at

mMC011785

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)

Other forms of this molecule

Cdc16 [cytosol]

Inferred From

CDC16 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_081552.2

ENSEMBL

ENSMUST00000043962, ENSMUSP00000047950, ENSMUSG00000038416

PRO

Q8R349

MGI

1917207

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.564	3
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.564	2
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.564	3
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.564	2
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.564	3

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