Reactome | Cdc27 [cytosol]

Cdc27 [cytosol]

Stable Identifier

R-MMU-174073

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CDC27, A2A6Q5

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Cyclin B (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        APC/C:Cdc20 mediated degradation of Securin (Mus musculus)
        
        Association of Securin with Cdc20:APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Securin (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
        
        APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
        
        Association of Nek2A with MCC:APC/C (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation of multiubiquitinated Nek2A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Multiubiquitination of Nek2A (Mus musculus)
        
        Multiubiquitinated Nek2A [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
        
        Association of Cyclin A with the APC/C (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Degradation multiubiquitinated Cyclin A (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
        
        Association of Cdh1 with the APC/C (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        Dissociation of Cdc20 from APC/C complex (Mus musculus)
        
        CDC20:p-APC/C [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
        
        Binding of the MCC complex to the APC/C complex (Mus musculus)
        
        MCC:APC/C complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        APC/C E3 ligase complex [cytosol] (Mus musculus)
        
        Cdc27 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:A2A6Q5

Gene Names

Cdc27

Reference Genes

BioGPS Gene:217232 Cdc27

ENSEMBL:ENSMUSG00000020687

ENSEMBL:ENSMUSG00000020687.14 Cdc27

KEGG Gene (Mus musculus):217232 Cdc27

Monarch:217232 Cdc27

NCBI Gene:217232 Cdc27

UCSC:A2A6Q5 Cdc27

Reference Transcript

Other Identifiers

10392012

112728_at

115813_at

132740_r_at

1426076_at

1433848_at

1433849_at

1454739_at

17270648

217232

4342148

4388464

4406861

4449678

4531457

4547834

4549311

4652145

4675069

4754698

4825414

4843522

4857222

4957771

4990975

5046932

5093617

5108259

5145483

5237159

5291336

5364814

5400945

5448591

5542185

A_52_P376841

A_55_P2061525

A_55_P2064478

A_65_P19769

GE131280

GO:0000278

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005856

GO:0007059

GO:0007091

GO:0016567

GO:0019903

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0051301

GO:0070979

GO:0072686

ILMN_1222385

ILMN_2515768

ILMN_2991534

mMR028485

Participates

as a component of

Other forms of this molecule

Cdc27 [nucleoplasm]

Inferred From

CDC27 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_663411.2, NP_001272917.1, XP_006533113.1

Ensembl

ENSMUSG00000020687, ENSMUST00000093923, ENSMUSP00000102575, ENSMUSP00000091452, ENSMUST00000106962

PRO

A2A6Q5

MGI

102685

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.499	2

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