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Cdc23 [cytosol]
Stable Identifier
R-MMU-174137
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CDC23, Q8BGZ4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
Mitotic Spindle Checkpoint (Mus musculus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
Binding of the MCC complex to the APC/C complex (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Separation of Sister Chromatids (Mus musculus)
Association of Securin with Cdc20:APC/C complex (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Securin (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation of multiubiquitinated cell cycle proteins (Mus musculus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Mus musculus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of Cyclin B (Mus musculus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Cyclin B (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Mus musculus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
APC/C:Cdc20 mediated degradation of Securin (Mus musculus)
Association of Securin with Cdc20:APC/C complex (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Securin (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)
CDC20:p-APC/C:PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Mus musculus)
APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
Association of Nek2A with MCC:APC/C (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation of multiubiquitinated Nek2A (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Multiubiquitination of Nek2A (Mus musculus)
Multiubiquitinated Nek2A [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Nek2A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Mus musculus)
Association of Cyclin A with the APC/C (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Degradation multiubiquitinated Cyclin A (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Mus musculus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
Association of Cdh1 with the APC/C (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Dissociation of Cdc20 from APC/C complex (Mus musculus)
CDC20:p-APC/C [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Mus musculus)
Binding of the MCC complex to the APC/C complex (Mus musculus)
MCC:APC/C complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
S Phase (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
CDK-mediated phosphorylation and removal of Cdc6 (Mus musculus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)
phospho-APC/C:Cdh1 complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
APC/C E3 ligase complex [cytosol] (Mus musculus)
Cdc23 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8BGZ4
Gene Names
Cdc23
Reference Genes
BioGPS Gene:52563 Cdc23
ENSEMBL:ENSMUSG00000024370
KEGG Gene (Mus musculus):52563 Cdc23
Monarch:52563 Cdc23
NCBI Gene:52563 Cdc23
UCSC:Q8BGZ4 Cdc23
Reference Transcript
RefSeq:NM_178347.4 Cdc23
Participates
as a component of
APC/C E3 ligase complex [cytosol] (Mus musculus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Mus musculus)
Other forms of this molecule
Cdc23 [nucleoplasm]
Inferred From
CDC23 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_848124.1
PRO
Q8BGZ4
MGI
1098815
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.564
4
UniProt:P51955 NEK2
1
NEK2 [cytosol]
(R-HSA-177329)
0.564
4
UniProt:Q9UKT4 FBXO5
6
p-FBXO5 [nucleoplasm]
(R-HSA-163049)
p-S145,S149-FBXO5 [nucleoplasm]
(R-HSA-174220)
p-S182-FBXO5 [nucleoplasm]
(R-HSA-176447)
FBXO5 [nucleoplasm]
(R-HSA-174060)
p-S145,S149-FBXO5 [cytosol]
(R-HSA-174207)
p-S182-FBXO5 [cytosol]
(R-HSA-177324)
0.564
3
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.564
3
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.564
2
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