Reactome | Cdc26 [nucleoplasm]

Cdc26 [nucleoplasm]

Stable Identifier

R-MMU-174216

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CDC26, Q99JP4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        Phosphorylation of the APC/C (Mus musculus)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Free APC/C phosphorylated by Plk1 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc26 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99JP4

Gene Names

Cdc26

Reference Genes

BioGPS Gene:66440 Cdc26

ENSEMBL:ENSMUSG00000066149

KEGG Gene (Mus musculus):66440 Cdc26

Monarch:66440 Cdc26

NCBI Gene:66440 Cdc26

UCSC:Q99JP4 Cdc26

Reference Transcript

Other Identifiers

10513583

1423987_at

1452992_at

1456860_at

17426166

4317960

4429734

4489947

4510377

4612668

4640509

4710096

4746399

4751014

4755427

4819045

4963431

4972201

5055902

5151451

5169162

5171567

5200317

5260448

5310713

5332596

5353039

5378441

5412873

5551744

5568962

5612106

66440

94084_at

A_51_P353663

A_52_P50959

A_52_P649285

A_55_P2139112

GE39240

GO:0000278

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005680

GO:0006464

GO:0007049

GO:0007059

GO:0007346

GO:0008150

GO:0009056

GO:0016567

GO:0030071

GO:0031145

GO:0032991

GO:0043226

GO:0051276

GO:0051301

GO:0070979

GO:0140014

ILMN_2445936

ILMN_2588986

aa419863_s_at

mMC013087

mMR028627

Participant Of

hasComponent

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm]

Other forms of this molecule

Cdc26 [cytosol]

Inferred From

CDC26 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_647452.1, XP_006538236.1

Ensembl

ENSMUSP00000081573, ENSMUSG00000066149, ENSMUSP00000120496, ENSMUST00000084525, ENSMUST00000134727, ENSMUST00000107459, ENSMUSP00000103083

PRO

Q99JP4

MGI

1913690

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.564	3
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.564	3
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) p-S182-FBXO5 [cytosol] (R-HSA-177324) p-FBXO5 [nucleoplasm] (R-HSA-163049) FBXO5 [nucleoplasm] (R-HSA-174060)	0.564	2
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.564	3

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