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Cul1 [cytosol]
Stable Identifier
R-MMU-174230
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CUL1, Q9WTX6
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Mus musculus)
Formation of the SCF-FBXL7 complex (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-FBXL7 ubiquitinates AURKA (Mus musculus)
SCF-FBXL7:AURKA [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF:FBXL7 binds AURKA (Mus musculus)
SCF-FBXL7:AURKA [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Regulation of PLK1 Activity at G2/M Transition (Mus musculus)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Prolactin receptor signaling (Mus musculus)
PRLR binds SCF beta-TrCP complex (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Prolactin receptor is internalized (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
TNFR2 non-canonical NF-kB pathway (Mus musculus)
NIK-->noncanonical NF-kB signaling (Mus musculus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
Dectin-1 mediated noncanonical NF-kB signaling (Mus musculus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Mus musculus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Mus musculus)
CUL1:FBXW11:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog 'off' state (Mus musculus)
Degradation of GLI1 by the proteasome (Mus musculus)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
GLI3 is processed to GLI3R by the proteasome (Mus musculus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Signaling by WNT (Mus musculus)
Degradation of beta-catenin by the destruction complex (Mus musculus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Mus musculus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Transport of small molecules (Mus musculus)
Iron uptake and transport (Mus musculus)
CANDI binds CUL1 (Mus musculus)
CANDI:CUL1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
CUL1, SKP1, FBXL5 bind (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:CUL1:FBXL5 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)
SKP1:CUL1:FBXL5 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Mus musculus)
SKP1:CUL1:FBXL5 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Mus musculus)
SKP1:CUL1:FBXL5 [cytosol] (Mus musculus)
Cul1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WTX6 Cul1
Gene Names
Cul1
Chain
chain:1-776
Reference Genes
BioGPS Gene:26965 Cul1
ENSEMBL:ENSMUSG00000029686 Cul1
KEGG Gene (Mus musculus):26965 Cul1
Monarch:26965 Cul1
NCBI Gene:26965 Cul1
UCSC:Q9WTX6 Cul1
Reference Transcript
RefSeq:NM_012042.3 Cul1
RefSeq:XM_006506190.3 Cul1
RefSeq:XM_006506189.3 Cul1
RefSeq:XM_006506188.3 Cul1
Other Identifiers
10537882
1448174_at
17458074
26965
4322545
4384516
4395363
4397665
4400116
4408214
4409966
4435294
4473544
4541793
4549578
4699993
4765131
4817283
4899606
4934977
4939861
4989193
5025562
5140209
5145975
5234906
5236058
5307773
5372266
5418750
5438950
5541274
5553124
94002_at
A_52_P149250
A_52_P664699
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006464
GO:0006511
GO:0006513
GO:0006915
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009887
GO:0016032
GO:0016567
GO:0019005
GO:0019899
GO:0031146
GO:0031461
GO:0031625
GO:0032991
GO:0043161
GO:0043226
GO:0044403
GO:0048856
GO:0061630
GO:0070936
GO:1990452
ILMN_1226323
mMC009289
Participant Of
hasMember
E3 ligases in proteasomal degradation [cytosol]
hasComponent
BTRC:CUL1:RBX1:SKP1 [cytosol]
BTRC:CUL1:SKP1 [cytosol]
CANDI:CUL1 [cytosol]
CUL1:FBXW11:SKP1 [cytosol]
SCF E3 ubiquitin ligase [cytosol]
SKP1:CUL1:FBXL5 [cytosol]
SKP1:CUL1:RBX1:FBXL18 [cytosol]
SKP1:CUL1:RBX1:FBXL7 [cytosol]
input
CANDI binds CUL1
CUL1, SKP1, FBXL5 bind
Formation of the SCF-FBXL7 complex
Other forms of this molecule
Cul1 [cytosol]
Cul1 [nucleoplasm]
Inferred From
CUL1 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_006506251.1
,
XP_006506252.1
,
XP_006506253.1
,
NP_036172.1
Ensembl
ENSMUSP00000031697
,
ENSMUST00000031697
,
ENSMUSG00000029686
PRO
Q9WTX6
MGI
1349658
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.499
2
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.499
3
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