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Nfkb1 [nucleoplasm]
Stable Identifier
R-MMU-177655
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
NFKB1(1-433), P25799
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)
p-S536-RELA:NFKB1(1-433) [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
PKMTs methylate histone lysines (Mus musculus)
SETD6 methylates RELA in the NFkB complex (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NFkB Complex with MeK310-RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)
NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] (Mus musculus)
NF-kappaB p50:c-Rel [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NF-kappaB p50:p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 processing (Mus musculus)
Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Interleukin-1 signaling (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CD209 (DC-SIGN) signaling (Mus musculus)
CBP and p300 binds NF-kB complex (Mus musculus)
NFKB1:p-S276-RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
p300 acetylates RELA subunit (Mus musculus)
NFKB1:p-S276,5AcK-RELA:p300/CBP [nucleoplasm] (Mus musculus)
NFKB1:p-S276,5AcK-RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Mus musculus)
NFkB complex translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
ZBP1(DAI) mediated induction of type I IFNs (Mus musculus)
RIP-mediated NFkB activation via ZBP1 (Mus musculus)
NFkB complex translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Mus musculus)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
NF-kB migrates to the nucleus and turns on transcription (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
Nfkb1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P25799
Gene Names
Nfkb1
Reference Genes
BioGPS Gene:18033 NFKB1
ENSEMBL:ENSMUSG00000028163
KEGG:mmu:18033 NFKB1
Monarch:18033 NFKB1
NCBI Gene:18033 NFKB1
UCSC:P25799 NFKB1
Reference Transcript
RefSeq:XM_006501106.2 NFKB1
RefSeq:NM_008689.2 NFKB1
Participates
as a component of
p-S536-RELA:NFKB1(1-433) [nucleoplasm] (Mus musculus)
NFKB1:p-S276,5AcK-RELA [nucleoplasm] (Mus musculus)
NFKB1:p-S276-RELA [nucleoplasm] (Mus musculus)
NF-kappaB p50:c-Rel [nucleoplasm] (Mus musculus)
NF-kappaB p50:p50 [nucleoplasm] (Mus musculus)
NFKB1(1-433):RELA [nucleoplasm] (Mus musculus)
as a member of
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Mus musculus)
Other forms of this molecule
phospho-Nfkb1 [cytosol]
phospho-Nfkb1 [cytosol]
Nfkb1 [cytosol]
Nfkb1 [cytosol]
Nfkb1 [secretory granule lumen]
Nfkb1 [extracellular region]
Nfkb1 [specific granule lumen]
Inferred From
NFKB1(1-433) [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_032715.2
,
XP_006501169.1
ENSEMBL
ENSMUSP00000029812
,
ENSMUSP00000128345
,
ENSMUST00000029812
,
ENSMUSG00000028163
,
ENSMUST00000164430
PRO
P25799
MGI
97312
GlyGen
P25799
PDB
1VKX
,
1U36
,
2I9T
,
1OOA
,
1U42
,
1U41
,
1NFK
,
1U3J
,
1LEI
,
1BFS
,
8TKL
,
8TKN
,
1LE5
,
1IKN
,
2V2T
,
8TKM
,
1LE9
,
3JV4
,
1U3Y
,
1U3Z
,
9BOR
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04207
7
Rela [nucleoplasm]
(R-MMU-177676)
Rela [cytosol]
(R-MMU-168172)
phospho-Rela [nucleoplasm]
(R-MMU-5624468)
phospho-Rela [nucleoplasm]
(R-MMU-5660642)
Rela [nucleoplasm]
(R-MMU-4755466)
phospho-Rela [nucleoplasm]
(R-MMU-9861499)
Rela [nucleoplasm]
(R-MMU-8865233)
0.844
7
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.508
2
UniProt:O09106 Hdac1
2
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-MMU-4616030)
Hdac1 [nucleoplasm]
(R-MMU-573340)
0.499
2
UniProt:Q9DBR0 AKAP8
0.499
4
UniProt:P25799
8
phospho-Nfkb1 [cytosol]
(R-MMU-451619)
phospho-Nfkb1 [cytosol]
(R-MMU-451611)
Nfkb1 [cytosol]
(R-MMU-451607)
Nfkb1 [nucleoplasm]
(R-MMU-177655)
Nfkb1 [cytosol]
(R-MMU-168168)
Nfkb1 [secretory granule lumen]
(R-MMU-6801004)
Nfkb1 [extracellular region]
(R-MMU-6806304)
Nfkb1 [specific granule lumen]
(R-MMU-6799557)
0.482
2
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