Mouse pro-EGF is cleaved by ADAM sheddases

Stable Identifier
R-MMU-179883
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Mouse pro-EGF is cleaved by ADAM sheddases
Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized.
Literature References
PubMed ID Title Journal Year
16054021 ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk

Nanba, D, Higashiyama, S

Biochim Biophys Acta 2005
Participants
Catalyst Activity

metalloendopeptidase activity of ADAM metalloprotease:Zinc cofactor [plasma membrane]

Orthologous Events
Created
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