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Tbk1 [cytosol]
Stable Identifier
R-MMU-1810477
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-37 signaling (Mus musculus)
TBK1 phosphorylation (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
STING mediated induction of host immune responses (Mus musculus)
IRF3-mediated induction of type I IFN (Mus musculus)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
STAT6-mediated induction of chemokines (Mus musculus)
STING recruits TBK1 and STAT6 (Mus musculus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
Negative regulators of DDX58/IFIH1 signaling (Mus musculus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3:TBK1/IKKi [cytosol] (Mus musculus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Mus musculus)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Mus musculus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Mus musculus)
Tbk1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WUN2 Tbk1
Gene Names
Tbk1
Chain
chain:1-729
Reference Genes
BioGPS Gene:56480 Tbk1
ENSEMBL:ENSMUSG00000020115 Tbk1
KEGG Gene (Mus musculus):56480 Tbk1
Monarch:56480 Tbk1
NCBI Gene:56480 Tbk1
UCSC:Q9WUN2 Tbk1
Reference Transcript
RefSeq:NM_019786.4 Tbk1
Other Identifiers
10372853
1422469_at
1460315_s_at
17245488
4335136
4345558
4355811
4531251
4551086
4735410
4817256
4860585
4893102
4895715
4932712
4954614
5080532
5083240
5092588
5118097
5223573
5308606
5331374
5337742
5419176
5513820
56480
98087_at
A_51_P169850
A_52_P532029
GE37612
GO:0000166
GO:0002218
GO:0002376
GO:0003674
GO:0003676
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006914
GO:0006950
GO:0007165
GO:0008150
GO:0008283
GO:0009056
GO:0009058
GO:0010468
GO:0010629
GO:0016239
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019903
GO:0031323
GO:0032479
GO:0032727
GO:0032728
GO:0034641
GO:0042802
GO:0043123
GO:0043167
GO:0043226
GO:0043231
GO:0044565
GO:0045087
GO:0045944
GO:0050830
GO:0051219
GO:0051607
GO:0060340
GO:1904417
ILMN_1241535
mMC018910
Participant Of
input
Recruitment Tbk1 to dsDNA:Dai followed by its activation
STING recruits TBK1 and STAT6
TBK1 phosphorylation
hasComponent
STING:TBK1:IRF3 [cytoplasmic vesicle membrane]
STING:TBK1:STAT6 [cytoplasmic vesicle membrane]
hasMember
IKK related kinases TBK1/IKK epsilon [cytosol]
Other forms of this molecule
phospho-Tbk1 [cytosol]
p-S172-Tbk1 [cytosol]
phospho-Tbk1 [cytosol]
Inferred From
TBK1 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_062760.3
ZINC - Investigational
TBK1_MOUSE
IntEnz
2.7.11.1
ZINC - Substances
TBK1_MOUSE
ZINC target
Q9WUN2
Ensembl
ENSMUST00000020316
,
ENSMUSG00000020115
,
ENSMUSP00000020316
PRO
Q9WUN2
MGI
1929658
ZINC - Predictions - Purchasable
TBK1_MOUSE
PDB
6O8C
,
4JLC
,
4JL9
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P70347
2
Tank [cytosol]
(R-MMU-5362480)
Tank [cytosol]
(R-MMU-933407)
0.75
7
UniProt:Q9WUN2 Tbk1
4
p-S172-Tbk1 [cytosol]
(R-MMU-1810465)
phospho-Tbk1 [cytosol]
(R-MMU-3249397)
phospho-Tbk1 [cytosol]
(R-MMU-9008705)
Tbk1 [cytosol]
(R-MMU-1810477)
0.719
5
UniProt:Q80UF7
1
Ticam1 [cytosol]
(R-MMU-166170)
0.589
2
UniProt:Q3TBT3
5
Sting1 [secretory granule membrane]
(R-MMU-6804798)
Sting1 [plasma membrane]
(R-MMU-6804815)
Sting1 [endoplasmic reticulum membrane]
(R-MMU-3134805)
Sting1 [cytoplasmic vesicle membrane]
(R-MMU-3248021)
Sting1 [endoplasmic reticulum membrane]
(R-MMU-1834940)
0.564
3
UniProt:A2A9T0 TBKB1
0.499
2
UniProt:O41932 O41932
0.463
3
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