HNF1a transactivates Glut2

Stable Identifier
R-MMU-186469
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HNF1a transactivates Glut2
Hnf1a (Tcf1) has been shown to activate the Glut2 gene in rat INS1 cells (Wang et al. 1999). It has been shown to bind the GLUT2 gene in mouse islets by chromatin immunoprecipitation, and decreased expression is observed in Hnf1a-/- islets (Parrizas et al, 2001). Glut2 expression in the developing pancreas in vivo is lost by embryonic day 18.5 in mice lacking a functional Hnf1a gene (Boj et al. 2001).
Literature References
PubMed ID Title Journal Year
11717395 A transcription factor regulatory circuit in differentiated pancreatic cells

Boj, SF, Parrizas, M, Maestro, MA, Ferrer, J

Proc Natl Acad Sci U S A 2001
11287626 Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

Parrizas, M, Maestro, MA, Boj, SF, Paniagua, A, Casamitjana, R, Gomis, R, Rivera, F, Ferrer, J

Mol Cell Biol 2001
9822613 Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line

Wang, H, Maechler, P, Hagenfeldt, KA, Wollheim, CB

EMBO J 1998
Participants
Output
This event is regulated
Positively by
Regulator
hnf1-alpha/tcf1 [nucleoplasm] (Mus musculus)
Orthologous Events
HNF1A-dependent synthesis of GLUT2 protein (Homo sapiens)
Authored
Ferrer, J  (2008-05-24)
Tello-Ruiz, MK  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-08-14)
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