HNF1b transactivates Ptf1a

Stable Identifier
R-MMU-187247
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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HNF1b transactivates Ptf1a

Lack of TCF2 disrupts early pancreas development. Specifically, Tcf2-deficient mice lack expression of Ptf1a, a key transcription factor for the acquisition of a pancreatic fate (Haumaitre et al. 2005).

Literature References
PubMed ID Title Journal Year
15668393 Lack of TCF2/vHNF1 in mice leads to pancreas agenesis

Haumaitre, C, Barbacci, E, Jenny, M, Ott, MO, Gradwohl, G, Cereghini, S

Proc Natl Acad Sci U S A 2005
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