Reactome | Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]

Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]

Stable Identifier

R-MMU-187926

Type

Complex

Species

Mus musculus

Compartment

nucleoplasm

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDKN1A,CDKN1B [nucleoplasm] (Mus musculus)

Participates

as an input of

Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)

as an output of

Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)

This entity regulates

Negatively

CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)

Inferred From

Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)

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