Double Fgf10/Hnf6 KO studies have shown that these two proteins play redundant roles in the maintenance of Pdx1 expression in the early pancreatic bud. Thus, while Hnf6 KO embryos have delayed expression of Pdx1, and Fgf10-deficient embryos have only a partial reduction in the Pdx1, Fgf10/Hnf6 double mutant embryos fail to generate pancreatic buds.
Bhushan, A, Itoh, N, Kato, S, Thiery, JP, Czernichow, P, Bellusci, S, Scharfmann, R
Jacquemin, P, Yoshitomi, H, Kashima, Y, Rousseau, GG, Lemaigre, FP, Zaret, KS
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