FGF10 activates Pdx1 expression in the developing early pancreatic bud

Stable Identifier
R-MMU-190088
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FGF10 activates Pdx1 expression in the developing early pancreatic bud
Double Fgf10/Hnf6 KO studies have shown that these two proteins play redundant roles in the maintenance of Pdx1 expression in the early pancreatic bud. Thus, while Hnf6 KO embryos have delayed expression of Pdx1, and Fgf10-deficient embryos have only a partial reduction in the Pdx1, Fgf10/Hnf6 double mutant embryos fail to generate pancreatic buds.
Literature References
PubMed ID Title Journal Year
16386727 An endothelial-mesenchymal relay pathway regulates early phases of pancreas development

Rousseau, GG, Zaret, KS, Jacquemin, P, Lemaigre, FP, Kashima, Y, Yoshitomi, H

Dev Biol 2006
11748146 Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis

Itoh, N, Kato, S, Bellusci, S, Thiery, JP, Czernichow, P, Bhushan, A, Scharfmann, R

Development 2001
Participants
Output
This event is regulated
Positively by
Regulator
fgf10 [extracellular region] (Mus musculus)
Orthologous Events
HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-12-18)
Cite Us!