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Arhgef6 [cytosol]
Stable Identifier
R-MMU-195017
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
ARHGEF6, Q8K4I3
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Mus musculus)
Cell junction organization (Mus musculus)
Cell-extracellular matrix interactions (Mus musculus)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Mus musculus)
PARVB/Affixin interacts with alpha PIX (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
ParvB/Affixin:Alpha-Pix [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through CDC42 (Mus musculus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
PAK1 binds ARHGEF6 (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Mus musculus)
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
CDC42 GTPase cycle (Mus musculus)
CDC42 GEFs activate CDC42 (Mus musculus)
CDC42 GEFs [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
Arhgef6 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8K4I3
Gene Names
Arhgef6
Reference Genes
BioGPS Gene:73341 Arhgef6
ENSEMBL:ENSMUSG00000031133
ENSEMBL:ENSMUSG00000031133.13 Arhgef6
KEGG Gene (Mus musculus):73341 Arhgef6
Monarch:73341 Arhgef6
NCBI Gene:73341 Arhgef6
Reference Transcript
RefSeq:NM_152801.2 Arhgef6
Other Identifiers
10604713
111718_at
113761_at
1429012_at
17541875
4471685
4561686
4687041
4688547
4798695
4822170
4844081
4881313
4933544
4993083
5010280
5022990
5113548
5117676
5136797
5167289
5183670
5227989
5259313
5283609
5410261
5428845
5478751
5498816
5564831
73341
A_52_P290020
A_55_P1964573
GE39014
GO:0005085
GO:0005515
GO:0005737
GO:0005911
GO:0023052
GO:0030027
GO:0030032
GO:0035556
GO:0042995
GO:0098772
ILMN_2639642
ILMN_2751345
mMC020754
mMC022675
Participates
as a candidate of
CDC42 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
as an output of
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)
as an input of
PAK1 binds ARHGEF6 (Mus musculus)
PARVB/Affixin interacts with alpha PIX (Mus musculus)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Mus musculus)
ParvB/Affixin:Alpha-Pix [cytosol] (Mus musculus)
as a member of
GEFs [cytosol] (Mus musculus)
Inferred From
ARHGEF6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_690014.2
Ensembl
ENSMUSG00000031133
,
ENSMUST00000033468
,
ENSMUSP00000033468
PRO
Q8K4I3
MGI
1920591
PDB
1V61
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HBI1 PARVB
1
PARVB [cytosol]
(R-HSA-446016)
0.463
3
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