Reactome | Trem2 [plasma membrane]

Trem2 [plasma membrane]

Stable Identifier

R-MMU-197664

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

TREM2, Q99NH8

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - Semaphorin interactions (Mus musculus)
      - Other semaphorin interactions (Mus musculus)
        
        SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)
        
        PLXNA1:TREM2:DAP12 [plasma membrane] (Mus musculus)
        
        DAP12 dimer:TREM2 [plasma membrane] (Mus musculus)
        
        Trem2 [plasma membrane] (Mus musculus)
        
        SEMA6D:PLXNA1:TREM2:DAP12 [plasma membrane] (Mus musculus)
        
        PLXNA1:TREM2:DAP12 [plasma membrane] (Mus musculus)
        
        DAP12 dimer:TREM2 [plasma membrane] (Mus musculus)
        
        Trem2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99NH8

Gene Names

Trem2

Reference Genes

BioGPS Gene:83433 Trem2

ENSEMBL:ENSMUSG00000023992

ENSEMBL:ENSMUSG00000116470 Trem2

KEGG Gene (Mus musculus):83433 Trem2

Monarch:83433 Trem2

NCBI Gene:83433 Trem2

UCSC:Q99NH8 Trem2

Reference Transcript

Other Identifiers

10445781

1421792_s_at

17338416

4434185

4441376

4538412

4693084

5273408

5359043

5361242

83433

A_51_P269546

A_51_P269549

A_55_P1962937

GE125741

GO:0001530

GO:0001540

GO:0001774

GO:0001934

GO:0002282

GO:0002376

GO:0002588

GO:0002931

GO:0003674

GO:0004888

GO:0005515

GO:0005543

GO:0005575

GO:0005576

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006911

GO:0006914

GO:0006950

GO:0007005

GO:0007165

GO:0008035

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0009056

GO:0009058

GO:0010468

GO:0010507

GO:0010628

GO:0010822

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0019899

GO:0030154

GO:0030169

GO:0030316

GO:0031226

GO:0031663

GO:0032006

GO:0032008

GO:0032497

GO:0032499

GO:0032675

GO:0032691

GO:0032720

GO:0032733

GO:0034185

GO:0034186

GO:0034189

GO:0034241

GO:0034330

GO:0034641

GO:0038023

GO:0040011

GO:0042742

GO:0042834

GO:0043066

GO:0043167

GO:0043277

GO:0044281

GO:0044877

GO:0045087

GO:0045088

GO:0045672

GO:0048143

GO:0048646

GO:0048856

GO:0048870

GO:0050714

GO:0050730

GO:0050731

GO:0050850

GO:0050921

GO:0055085

GO:0060075

GO:0060100

GO:0061024

GO:0061518

GO:0070374

GO:0070392

GO:0070891

GO:0071223

GO:0071224

GO:0071640

GO:0071813

GO:0097028

GO:0097110

GO:0097242

GO:0098657

GO:0120035

GO:0150062

GO:0150076

GO:0150078

GO:1900223

GO:1901076

GO:1901224

GO:1901800

GO:1901980

GO:1902531

GO:1903078

GO:1903082

GO:1903980

GO:1904093

GO:1904141

GO:1904646

GO:1905291

GO:1990782

GO:2000350

GO:2001171

ILMN_2490540

ILMN_2992709

mMC000876

Participant Of

hasMember

input

Interaction of DAP12 and TREM2

hasComponent

DAP12 dimer:TREM2 [plasma membrane]

Inferred From

TREM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001259007.1, NP_112544.1

Ensembl

ENSMUSP00000108863, ENSMUSP00000155680, ENSMUSP00000154941, ENSMUSP00000024791, ENSMUST00000024791, ENSMUSG00000116470, ENSMUST00000231062, ENSMUST00000113237, ENSMUSG00000023992, ENSMUST00000229587

PRO

Q99NH8

MGI

1913150

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P70206 Plxna1	4	pPlexin-A1 [plasma membrane] (R-MMU-421082) Plxna1 [plasma membrane] (R-MMU-421079) Plxna1 [plasma membrane] (R-MMU-396932) phospho-Plxna1 [plasma membrane] (R-MMU-419614)	0.558	4
UniProt:P05067-PRO_0000000092 APP			0.544	2

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